5-Bromoisoquinoline
5-Bromoisoquinoline is a brominated isoquinoline building block with the molecular formula C9H6BrN and a molecular weight of 208.05 g/mol (CAS 34784-04-8). Supplied at 98% assay as a crystalline solid (melting point 83-87 °C), it is a halogenated heterocyclic intermediate used in chemical synthesis. The aryl bromide is a versatile handle for palladium-catalysed coupling, making this compound a useful starting material in medicinal chemistry and discovery research. Tech Serve Solutions supplies and exports it worldwide.
- Synonyms
- 5-Bromoisoquinoline34784-04-8C9H6BrNMFCD016464055-bromo-isoquinoline
Palladium-catalysed amination
The carbon-bromine bond serves as a reactive site in palladium-catalysed amination (Buchwald-Hartwig type) reactions, enabling the introduction of nitrogen substituents onto the isoquinoline scaffold.
Palladium-catalysed aminomethylation
5-Bromoisoquinoline is employed as a starting material in palladium-catalysed aminomethylation reactions, providing access to functionalised aminomethyl isoquinoline derivatives.
Heterocyclic building block
As a halogenated isoquinoline, it acts as a building block in the construction of more elaborate nitrogen heterocycles and is a common intermediate in multi-step organic synthesis.
Cross-coupling intermediate
The aryl bromide functionality makes the compound a convenient substrate for transition-metal-catalysed cross-coupling chemistry, allowing carbon-carbon and carbon-heteroatom bond formation at the 5-position.
Research and discovery chemistry
It is used in laboratory and discovery-scale work where a defined isoquinoline core with a single reactive halogen is required to build candidate molecules.
| Molecular weight | 208.05 |
|---|---|
| Empirical formula | C9H6BrN |
| Assay | 98% |
| Application | Starting material employed in palladium-catalyzed aminomethylation1 and amination2 reactions. |
| Melting point | 83-87 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Bromoisoquinoline used for?
+
5-Bromoisoquinoline is used as a building block in organic and medicinal chemistry. Its aryl bromide handle is a starting material for palladium-catalysed amination and aminomethylation, as well as broader cross-coupling reactions that functionalise the isoquinoline scaffold.
What is the CAS number and molecular formula of 5-Bromoisoquinoline?
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The CAS number is 34784-04-8 and the molecular formula is C9H6BrN, with a molecular weight of 208.05 g/mol. Its MDL number is MFCD01646405 and the PubChem Substance ID is 24881493.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Bromoisoquinoline at 98% assay as a crystalline solid with a literature melting point of 83-87 °C. This is a research and synthesis grade material; a certificate of analysis can be provided with each batch on request.
What are the safety and handling precautions for 5-Bromoisoquinoline?
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It is classified under GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid raising dust, and follow precautions P261 and P305+P351+P338. It is rated WGK 3, indicating a severe hazard to water.
How is 5-Bromoisoquinoline packed, shipped and exported?
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The product is packed in tightly sealed, appropriately labelled containers sized to the order, from gram quantities to bulk. Tech Serve Solutions ships and exports worldwide with full documentation, including the safety data sheet and certificate of analysis.
How do I request a sample or quote for 5-Bromoisoquinoline?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time, packaging options and a quotation. Samples can be arranged on request.
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