5-Bromo-2,4-dichloropyrimidine
5-Bromo-2,4-dichloropyrimidine (CAS: 36082-50-5) is a halogenated heterocyclic compound with the molecular formula C4HBrCl2N2 and a molecular weight of 227.87 g/mol. This chemical serves as a valuable building block in organic synthesis. Its primary application lies in the preparation of trisubstituted pyrimidines, achieved through nucleophilic substitution and palladium-catalyzed cross-coupling reactions. It is supplied by Tech Serve Solutions with an assay of 97%.
- Synonyms
- C4HBrCl2N25-Bromopyrimidine, 2,4-dichloro-
Synthesis of Trisubstituted Pyrimidines
This compound is a key starting material for synthesizing complex trisubstituted pyrimidine structures. The synthesis involves sequential reactions including nucleophilic substitution and palladium-catalyzed aryl cross-coupling, enabling the construction of diverse molecular architectures.
Heterocyclic Chemistry Intermediate
As a halogenated pyrimidine derivative, it is frequently employed as an intermediate in heterocyclic chemistry. Its reactive halogen atoms provide handles for various functionalization strategies, facilitating the creation of novel heterocyclic compounds.
Research and Development in Organic Synthesis
5-Bromo-2,4-dichloropyrimidine is utilised in academic and industrial research laboratories for exploring new synthetic methodologies and developing novel organic molecules with potential applications in pharmaceuticals and materials science.
| Molecular weight | 227.87 |
|---|---|
| Empirical formula | C4HBrCl2N2 |
| Assay | 97% |
| Boiling point | 128 °C/15 mmHg(lit.) |
| Density | 1.781 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.603(lit.) |
| Application | Starting material for the synthesis of trisubstituted pyrimidines via a combination of nucleophilic substitution and palladium-catalyzed aryl cross-coupling.1 |
| Melting point | 29-30 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 2923 8/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Bromo-2,4-dichloropyrimidine used for?
+
5-Bromo-2,4-dichloropyrimidine is used as a starting material for the synthesis of trisubstituted pyrimidines via nucleophilic substitution and palladium-catalyzed cross-coupling reactions.
What are the CAS number and formula for 5-Bromo-2,4-dichloropyrimidine?
+
The CAS number is 36082-50-5 and the empirical formula (Hill notation) is C4HBrCl2N2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 5-Bromo-2,4-dichloropyrimidine with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product specifications.
How should 5-Bromo-2,4-dichloropyrimidine be handled safely?
+
5-Bromo-2,4-dichloropyrimidine is classified as Danger (GHS05, GHS06) with hazards including H301 + H311 + H331 (Toxic if swallowed, in contact with skin or if inhaled) and H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment such as eyeshields, face shields, gloves, and a respirator (type N100 US or P3 EN143) must be used. Handle in a well-ventilated area or fume hood. Refer to the Safety Data Sheet (SDS) for comprehensive handling information.
Is 5-Bromo-2,4-dichloropyrimidine a controlled substance?
+
The provided data does not indicate that 5-Bromo-2,4-dichloropyrimidine is a controlled substance.
How is 5-Bromo-2,4-dichloropyrimidine packed and shipped?
+
Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details are provided upon request and in compliance with international regulations for hazardous materials (UN 2923).
How can I request a quote or sample?
+
Please contact our sales team via the website or direct inquiry to request a quotation or a sample of 5-Bromo-2,4-dichloropyrimidine.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis