5-Bromo-1-(tert-butyldimethylsilyl)-1H-indole
5-Bromo-1-(tert-butyldimethylsilyl)-1H-indole (CAS: 331432-91-8) is a halogenated indole derivative with the molecular formula C14H20BrNSi and a molecular weight of 310.30 g/mol. This compound serves as a valuable building block in organic synthesis, particularly within the fields of medicinal chemistry and materials science. Its structure allows for further functionalisation, making it a key intermediate in the construction of complex heterocyclic systems.
- IUPAC
- 5-Bromo-1-TBDMS-1H-indole
Organic Synthesis Intermediate
This indole derivative is employed as a versatile intermediate in the synthesis of complex organic molecules. The bromine atom and the tert-butyldimethylsilyl (TBDMS) protecting group offer distinct points for selective chemical transformations.
Medicinal Chemistry Research
As a halogenated heterocyclic building block, it finds application in the development of novel pharmaceutical agents. The indole scaffold is prevalent in many biologically active compounds, and this bromo-indole allows for the exploration of new therapeutic candidates.
Materials Science
Derivatives of indole are explored for their properties in advanced materials. This compound can be used in the synthesis of functionalised indoles for applications such as organic electronics or specialised polymers.
| Molecular weight | 310.30 |
|---|---|
| Empirical formula | C14H20BrNSi |
| Assay | 97% |
| Boiling point | 158 °C/0.10 mmHg |
| Density | 1.224 g/mL at 25 °C |
| Refractive index | n20/D 1.574 |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Flash point | >110 °C / >230 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Bromo-1-(tert-butyldimethylsilyl)-1H-indole used for?
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5-Bromo-1-(tert-butyldimethylsilyl)-1H-indole is primarily used as a versatile building block and intermediate in organic synthesis, particularly for developing new compounds in medicinal chemistry and materials science.
What is the CAS number and molecular formula for this compound?
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The CAS number is 331432-91-8 and the empirical formula (Hill notation) is C14H20BrNSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Bromo-1-(tert-butyldimethylsilyl)-1H-indole with a minimum purity of 97%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling considerations for this chemical?
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This compound is classified as a Warning (GHS07) and may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment in a well-ventilated area. Store at 2-8°C.
How is this chemical packed, shipped, and exported?
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This chemical is available for purchase and export globally. Specific packaging details are available upon request and conform to international shipping regulations for chemical goods.
How can I request a sample or a quote?
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To request a sample or a quotation, please contact the TSS sales department through our website or by calling our customer service line.
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