5-(Aminomethyl)indole
5-(Aminomethyl)indole (CAS: 81881-74-5), with the molecular formula C9H10N2 and a molecular weight of 146.19 g/mol, is a key heterocyclic building block. This indole derivative serves as a crucial reactant in the synthesis of various biologically active molecules, including pharmaceutical intermediates. It is primarily utilised in research and development settings for the preparation of complex organic compounds with potential therapeutic applications.
- IUPAC
- Indole-5-methanamine
HIV-1 Integrase Inhibitors
Serves as a reactant in the preparation of compounds targeting the catalytic domain of HIV-1 integrase, with potential for interaction with LEDGF/p75. This application is crucial for developing new anti-HIV therapies.
Hedgehog Pathway Modulators
Utilised in the synthesis of inhibitors of Gli1-mediated transcription, which are key components in modulating the Hedgehog signalling pathway. This is relevant for cancer research and therapeutic development.
MAP Kinase Inhibitors
A precursor for SCIO-469-like compounds designed to inhibit p38 MAP kinase. Such inhibitors are investigated for their potential in treating inflammatory diseases.
PKC θ Inhibitors
Employed in the synthesis of novel thieno[2,3-b]pyridine-5-carbonitrile derivatives with potential as inhibitors of protein kinase c theta (PKC θ).
Thrombin Inhibitors
Acts as a building block in the development of non-covalent inhibitors of thrombin, a critical enzyme in the blood coagulation cascade.
| Molecular weight | 146.19 |
|---|---|
| Empirical formula | C9H10N2 |
| Assay | 95% |
| Application | Reactant for preparation of:• HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751• Inhibitors of Gli1-mediated transcription in the Hedgehog pathway2• SCIO-469-like compounds for the inhibition of p38 MAP kinase3• 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors4• Non-covalent thrombin inhibitors5 |
| Melting point | 114-122 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-(Aminomethyl)indole primarily used for?
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5-(Aminomethyl)indole is primarily used as a reactant in chemical synthesis for preparing potential pharmaceutical intermediates and biologically active molecules, including inhibitors for HIV-1 integrase, p38 MAP kinase, and PKC θ, as well as modulators of the Hedgehog pathway.
What are the CAS number and molecular formula of 5-(Aminomethyl)indole?
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The CAS number for 5-(Aminomethyl)indole is 81881-74-5, and its molecular formula is C9H10N2.
What grade and purity does Tech Serve Solutions supply for 5-(Aminomethyl)indole?
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Tech Serve Solutions supplies 5-(Aminomethyl)indole with an assay of 95%. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.
How should 5-(Aminomethyl)indole be handled safely?
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5-(Aminomethyl)indole is classified as harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation (H302-H315-H319-H335). Appropriate personal protective equipment, including a dust mask type N95, eyeshields, and gloves, should be used. Ensure adequate ventilation (P261, P305 + P351 + P338).
Is 5-(Aminomethyl)indole a controlled substance?
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The provided data does not indicate that 5-(Aminomethyl)indole is a controlled substance.
How is 5-(Aminomethyl)indole typically packed and shipped?
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Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details are available upon request and comply with all relevant regulations for chemical export.
How can I request a sample or quote for 5-(Aminomethyl)indole?
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To request a sample or obtain a quote for 5-(Aminomethyl)indole, please contact our sales department directly through the TSS website or by phone.
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