5-Aminoindole
5-Aminoindole (CAS 5192-03-0), with the chemical formula C8H8N2 and a molecular weight of 132.16 g/mol, is a key heterocyclic building block. This indole derivative is instrumental in the synthesis of various biologically active compounds. Its primary utility lies in its role as a reactant for developing novel molecules with potential therapeutic applications, including antitumoral agents and enzyme inhibitors.
- IUPAC
- 5-Indolamine,NSC 61452
Synthesis of Smac Mimetics
5-Aminoindole serves as a crucial reactant in the preparation of Smac mimetics. These compounds are designed to bind to the BIR2 domain of the anti-apoptotic protein XIAP, offering a potential therapeutic strategy in cancer treatment.
Development of Cytotoxic Agents
This compound is employed in the synthesis of agents exhibiting cytotoxic and antimitotic properties. Research indicates its utility in creating molecules that can impede cell division and induce cell death, relevant for antitumour research.
Preparation of IGF-1 Receptor Inhibitors
5-Aminoindole is utilised as a building block for synthesising insulin-like growth factor 1 receptor (IGF-1R) inhibitors. Such inhibitors are investigated for their potential in treating cancers where IGF-1R signalling plays a significant role.
Antitumoral Agent Synthesis
The chemical structure of 5-Aminoindole makes it a valuable precursor for the development of novel antitumoral agents. Its incorporation into molecular frameworks can lead to compounds with targeted cancer-fighting properties.
Factor Xa and Receptor Tyrosine Kinase Inhibitors
It functions as a reactant in synthesising inhibitors for biological targets such as Factor Xa and receptor tyrosine kinases. These inhibitors are explored for their antivascular and antiangiogenic effects in therapeutic research.
| Molecular weight | 132.16 |
|---|---|
| Empirical formula | C8H8N2 |
| Assay | 97% |
| Application | Reactant for preparation of:• Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP1• Cytotoxic and antimitotic agents2• Insulin-like growth factor 1 receptor inhibitors3• Antitumoral agents4• Factor Xa inhibitor5• Potential antivascular agents6• Gli1-mediated transcription in the Hedgehog pathway7• Inhibitors of receptor tyrosine kinase with antiangiogenic effects8• PKCθ inhibitors9• HIV protease inhibitors10 |
| Melting point | 131-133 °C (dec.)(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Aminoindole used for?
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5-Aminoindole (CAS 5192-03-0) is primarily used as a reactant in the synthesis of various biologically active compounds, including Smac mimetics, cytotoxic agents, insulin-like growth factor 1 receptor inhibitors, antitumoral agents, Factor Xa inhibitors, and potential antivascular agents.
What are the CAS number and formula for 5-Aminoindole?
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The CAS number for 5-Aminoindole is 5192-03-0, and its empirical formula (Hill notation) is C8H8N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Aminoindole with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades; it is suitable for research and chemical synthesis purposes.
What are the primary safety concerns when handling 5-Aminoindole?
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5-Aminoindole is classified with a 'Warning' signal word. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used.
How is 5-Aminoindole packaged and shipped?
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Tech Serve Solutions securely packages and exports fine chemicals globally. Specific packaging details are confirmed upon order, adhering to all relevant shipping regulations for chemical compounds.
How can I request a sample or quote for 5-Aminoindole?
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To request a sample or a quote for 5-Aminoindole, please use the contact form on our website or contact our sales department directly with your specific requirements.
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