5,8-Difluoro-4-hydroxyquinoline
5,8-Difluoro-4-hydroxyquinoline (CAS: 874781-10-9), with the molecular formula C9H5F2NO and a molar mass of 181.14 g/mol, is a specialised fluorinated heterocyclic building block. This compound is essential for intricate chemical synthesis, particularly in the development of novel pharmaceutical intermediates and advanced materials. Its unique difluoroquinoline structure offers valuable properties for researchers and chemists engaged in cutting-edge organic synthesis projects.
- Synonyms
- C9H5F2NO5,8-Difluoroquinolin-4-ol

Pharmaceutical Intermediate Synthesis
Utilised as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where fluorinated quinoline moieties are desired for enhanced biological activity or pharmacokinetic properties.
Organic Synthesis and Medicinal Chemistry
Serves as a versatile reagent for introducing fluorinated quinoline structures into complex organic molecules, facilitating research in drug discovery and development.
Material Science Research
Employed in the development of novel organic materials, where the electronic and structural properties conferred by the difluoroquinoline core can be advantageous.
| Molecular weight | 181.14 |
|---|---|
| Empirical formula | C9H5F2NO |


Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5,8-Difluoro-4-hydroxyquinoline used for?
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5,8-Difluoro-4-hydroxyquinoline is primarily used as a building block in organic synthesis, particularly for the development of pharmaceutical intermediates and novel materials.
What is the CAS number and formula for 5,8-Difluoro-4-hydroxyquinoline?
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The CAS number is 874781-10-9 and the molecular formula is C9H5F2NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical as a research or technical grade compound. We do not represent it as USP, BP, EP, or any pharmacopoeia standard unless explicitly stated.
What are the safety considerations for handling 5,8-Difluoro-4-hydroxyquinoline?
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This compound is classified as Dangerous. It causes serious eye damage (H318) and is harmful if swallowed (H302). Always handle with appropriate personal protective equipment, including eye protection and gloves, and ensure adequate ventilation.
How is 5,8-Difluoro-4-hydroxyquinoline packed and shipped?
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Products are carefully packed to ensure safe transit and are available for global export by Tech Serve Solutions, adhering to all relevant shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample, please contact our sales team through the website or direct email, providing your specific requirements.
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