5,6-Dihydro-4-methoxy-2H-pyran
5,6-Dihydro-4-methoxy-2H-pyran (CAS: 17327-22-9), with the molecular formula C6H10O2 and a molecular weight of 114.14 g/mol, is a valuable heterocyclic building block. This compound serves as a key reagent in organic synthesis, notably in the protection of chiral alcohols and in the solid-phase synthesis of oligonucleotides. Its chemical properties make it an important intermediate for various research and development applications.
- IUPAC
- 4-Methoxy-5,6-dihydropyran
- Synonyms
- 4-Methoxy-5,6-dihydropyran

Oligonucleotide Synthesis
Utilised in the solid-phase synthesis of oligoribonucleotides, facilitating the creation of complex nucleic acid structures.
Chiral Alcohol Protection
Acts as a reagent for the effective protection of chiral alcohol functionalities in organic synthesis, preserving stereochemical integrity.
Heterocyclic Synthesis
Serves as a fundamental building block within the synthesis of diverse heterocyclic compounds, contributing to the development of novel chemical entities.
| Molecular weight | 114.14 |
|---|---|
| Empirical formula | C6H10O2 |
| Assay | 95% |
| Boiling point | 59 °C/20 mmHg(lit.) |
| Density | 1.022 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.462(lit.) |
| Application | 5,6-Dihydro-4-methoxy-2H-pyran was used in solid-phase synthesis of series of oligoribonucleotides1. It was also used as reagent for the protection of chiral alcohols2,3. |

Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 46 °C / 114.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
| Safety statements (S) | 23-24/25 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5,6-Dihydro-4-methoxy-2H-pyran used for?
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5,6-Dihydro-4-methoxy-2H-pyran is used in organic synthesis, specifically for the protection of chiral alcohols and in the solid-phase synthesis of oligonucleotides. It is also a valuable heterocyclic building block.
What are the CAS number and formula for 5,6-Dihydro-4-methoxy-2H-pyran?
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The CAS number for 5,6-Dihydro-4-methoxy-2H-pyran is 17327-22-9, and its empirical formula is C6H10O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5,6-Dihydro-4-methoxy-2H-pyran with an assay of 95%. This is a technical/research grade; TSS does not represent it as USP, BP, or EP grade.
How should 5,6-Dihydro-4-methoxy-2H-pyran be handled safely?
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5,6-Dihydro-4-methoxy-2H-pyran is a flammable liquid and vapour (H226). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Avoid ignition sources.
Is 5,6-Dihydro-4-methoxy-2H-pyran available for export?
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Yes, Tech Serve Solutions, established in 1998, is a specialist global supplier and exporter of fine chemicals like 5,6-Dihydro-4-methoxy-2H-pyran.
How can I request a sample or quote for 5,6-Dihydro-4-methoxy-2H-pyran?
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To request a sample or quote, please contact our sales team via the website or by phone. Please specify the required quantity and your delivery location.
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