4α-Phorbol 12-myristate 13-acetate
4α-Phorbol 12-myristate 13-acetate (CAS: 63597-44-4), with the molecular formula C36H56O8 and a molecular weight of 616.83 g/mol, is a potent activator of Protein Kinase C (PKC). This white solid compound is primarily utilised in biological research to study cell signalling pathways, particularly those involving serine/threonine kinases. Its applications extend to cell biology and neuroscience research.
- IUPAC
- 4α-PMA
PKC Activation Studies
This compound serves as a research tool to activate Protein Kinase C (PKC) in vitro and in cellular models. It is instrumental in dissecting the downstream effects and signalling cascades regulated by PKC.
Cellular Signalling Research
Utilised to investigate cellular responses mediated by serine/threonine kinase activation. Its use helps researchers understand complex cell signalling networks in areas such as cell proliferation, differentiation, and apoptosis.
Neuroscience Research
Applied in neuroscience to explore the role of PKC signalling in neuronal function and development. It can help elucidate mechanisms underlying synaptic plasticity and neuronal survival.
Biochemical Assays
Serves as a standard or activator in biochemical assays designed to study kinase activity and substrate specificity, contributing to the characterisation of enzyme kinetics.
| Molecular weight | 616.83 |
|---|---|
| Empirical formula | C36H56O8 |
| Assay | ≥95% (TLC) |
| Form | solid |
| Colour | white |
| Solubility | H2O: ~2 μM (Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.)DMSO: solubleethanol: soluble |
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4α-Phorbol 12-myristate 13-acetate used for?
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4α-Phorbol 12-myristate 13-acetate is primarily used in research for activating Protein Kinase C (PKC) to study cell signalling pathways, cellular responses, and in neuroscience research.
What is the CAS number and formula for 4α-Phorbol 12-myristate 13-acetate?
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The CAS number is 63597-44-4 and the empirical formula is C36H56O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4α-Phorbol 12-myristate 13-acetate with a purity of ≥95% (TLC). This product is intended for research use only and is not supplied as USP, BP, EP, or pharmaceutical grade.
How should 4α-Phorbol 12-myristate 13-acetate be handled?
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Handle with appropriate personal protective equipment including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Store at -20°C. Consult the Safety Data Sheet for detailed handling and hazard information. WGK Germany is 3.
Is 4α-Phorbol 12-myristate 13-acetate a controlled substance?
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The provided data does not indicate that 4α-Phorbol 12-myristate 13-acetate is a controlled substance.
How is 4α-Phorbol 12-myristate 13-acetate shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. This product can be shipped and exported internationally according to relevant regulations.
How can I request a quote or sample?
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Please contact our sales team via the website or designated contact channels to request a quote or inquire about sample availability for 4α-Phorbol 12-myristate 13-acetate.
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