4-Pentenoyl chloride
4-Pentenoyl chloride (CAS 39716-58-0), with the linear formula H₂C=CHCH₂CH₂COCl and a molecular weight of 118.56 g/mol, is an acid halide. This reactive compound serves as a valuable building block in organic synthesis. It is primarily utilised in the preparation of specific peptide structures, notably contributing to the synthesis of acyclic tripeptides which can adopt a 3₁₀ helical conformation, and in subsequent cyclization reactions. Its primary applications lie within chemical research and development.
Peptide Synthesis
4-Pentenoyl chloride is employed in the preparation of acyclic tripeptides. These peptides can form a 3₁₀ helical conformation and are key intermediates in complex organic synthesis pathways.
Organic Building Block
As an acid halide and carbonyl compound, it functions as a versatile building block in organic synthesis. Its structure allows for the introduction of a pentenoyl group into various molecular frameworks.
Chemical Synthesis Intermediate
This compound is used in chemical synthesis for creating more complex molecules. Its reactivity facilitates reactions like acylation, enabling the construction of novel chemical entities.
| Molecular weight | 118.56 |
|---|---|
| Linear formula | H2C=CHCH2CH2COCl |
| Assay | 98% |
| Boiling point | 125 °C(lit.) |
| Density | 1.074 g/mL at 25 °C(lit.) |
| Application | Used in the preparation of an acyclic tripeptide containing a heterochiral D-pro-L-pro template with a propensity to exist as a 310 helical conformation. Cyclization via olefin metathesis (Grubbs Catalyst) provides the coresponding tetrapeptide without disruption of the helical conformation.1 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 27 °C / 80.6 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Pentenoyl chloride used for?
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4-Pentenoyl chloride is used in organic synthesis, particularly in the preparation of acyclic tripeptides that can adopt a 3₁₀ helical conformation and in subsequent cyclization reactions.
What is the CAS number and formula for 4-Pentenoyl chloride?
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The CAS number for 4-Pentenoyl chloride is 39716-58-0 and its linear formula is H₂C=CHCH₂CH₂COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Pentenoyl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
What are the main safety hazards associated with 4-Pentenoyl chloride?
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4-Pentenoyl chloride is a flammable liquid and vapour (H226) and causes severe skin burns and eye damage (H314). It requires handling with appropriate personal protective equipment, including face shields, gloves, and respirators, in a well-ventilated area.
Is 4-Pentenoyl chloride available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 4-Pentenoyl chloride.
How can I request a quote or sample for 4-Pentenoyl chloride?
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To request a quote or sample, please contact our sales team through the website or by phone. Our team will be happy to assist you with your inquiry.
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