4-Nitrophenyl trifluoroacetate
4-Nitrophenyl trifluoroacetate (CAS 658-78-6; CF3CO2C6H4NO2; MW 235.12) is a chemical reagent with significant utility in organic synthesis. Characterised by its trifluoroacetyl group, it acts as an effective trifluoroacetylating agent. This compound is particularly valuable in peptide chemistry for the protection of amino groups and in the synthesis of various organic intermediates. Its reactivity makes it a key component in coupling reactions and the modification of biomolecules.
Trifluoroacetylation Reagent
4-Nitrophenyl trifluoroacetate is a potent trifluoroacetylating agent, widely employed for the introduction of the trifluoroacetyl (CF3CO) group onto various substrates. This is crucial in modifying the properties of molecules for research or further synthetic steps.
Peptide Synthesis
In peptide chemistry, it serves as a reagent for the protection of amine functionalities. The trifluoroacetyl group can be introduced to amino acids or peptides, offering a stable protecting group that can be selectively removed later in the synthetic process.
Organic Synthesis Intermediate
This compound is utilized as a building block or intermediate in the synthesis of more complex organic molecules. Its reactive nature allows for diverse transformations, contributing to the development of novel chemical entities.
Coupling Reactions
4-Nitrophenyl trifluoroacetate can be involved in coupling reactions, facilitating the formation of new chemical bonds. Its ester linkage and activated phenyl ring contribute to its reactivity in these transformations.
| Molecular weight | 235.12 |
|---|---|
| Linear formula | CF3CO2C6H4NO2 |
| Assay | 99% |
| Boiling point | 120 °C/12 mmHg(lit.) |
| Melting point | 35-39 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Nitrophenyl trifluoroacetate used for?
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4-Nitrophenyl trifluoroacetate is primarily used as a trifluoroacetylating agent in organic synthesis, particularly for protecting amino groups in peptide chemistry and as an intermediate in the synthesis of other organic compounds. It is also employed in coupling reactions.
What is the CAS number and chemical formula for 4-Nitrophenyl trifluoroacetate?
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The CAS number for 4-Nitrophenyl trifluoroacetate is 658-78-6, and its chemical formula is CF3CO2C6H4NO2.
What grade and purity does Tech Serve Solutions supply for 4-Nitrophenyl trifluoroacetate?
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Tech Serve Solutions supplies 4-Nitrophenyl trifluoroacetate with a purity of 99% (assay). This product is not specified as USP, BP, EP, or other pharmacopoeia grades and is intended for research and technical use.
How should 4-Nitrophenyl trifluoroacetate be handled safely?
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4-Nitrophenyl trifluoroacetate is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Always use appropriate personal protective equipment, including eyeshields and gloves, and handle in a well-ventilated area or fume hood. Refer to the safety data sheet for detailed handling procedures.
Is 4-Nitrophenyl trifluoroacetate a controlled substance?
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Based on the provided data, 4-Nitrophenyl trifluoroacetate is not indicated as a controlled substance.
How is 4-Nitrophenyl trifluoroacetate packed and shipped?
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Tech Serve Solutions packs and exports fine chemicals like 4-Nitrophenyl trifluoroacetate in compliance with international shipping regulations for hazardous materials. Specific packaging details are available upon request.
How can I request a sample or quote for 4-Nitrophenyl trifluoroacetate?
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To request a sample or a quote for 4-Nitrophenyl trifluoroacetate, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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