4-Nitrophenyl phosphorodichloridate
4-Nitrophenyl phosphorodichloridate (CAS: 777-52-6), with the molecular formula O2NC6H4OP(O)Cl2 and a molecular weight of 255.98 g/mol, is a reactive organophosphorus compound. It serves as a crucial building block in organic synthesis and chemical research. This compound is primarily employed for phosphorylation reactions, enabling the introduction of the 4-nitrophenyl phosphate moiety into various substrates for advanced chemical applications.
- IUPAC
- 4-Nitrophenyl dichlorophosphate

Phosphorylation Agent
4-Nitrophenyl phosphorodichloridate is utilised for the phosphorylation of derivatized resins. This application highlights its utility in preparing functionalised materials for chemical processes and research.
Organic Synthesis Building Block
As a key intermediate, this compound facilitates the construction of more complex organic molecules. Its reactivity makes it valuable in diverse synthetic pathways within academic and industrial laboratories.
Chemical Research Reagent
It is employed in various research settings to explore novel chemical reactions and develop new compounds. Its specific chemical structure allows for targeted modifications in organic chemistry.
| Molecular weight | 255.98 |
|---|---|
| Linear formula | O2NC6H4OP(O)Cl2 |
| Assay | 98% |
| Boiling point | 182-183 °C/13 mmHg(lit.) |
| Application | 4-Nitrophenyl phosphorodichloridate was used to phosphorylate the derivatized resin1. |
| Melting point | 44-45 °C(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Nitrophenyl phosphorodichloridate used for?
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4-Nitrophenyl phosphorodichloridate is used in chemical synthesis, particularly for phosphorylation reactions, such as phosphorylating derivatized resins. It serves as an important building block in organic chemistry.
What are the CAS number and formula for 4-Nitrophenyl phosphorodichloridate?
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The CAS number for 4-Nitrophenyl phosphorodichloridate is 777-52-6, and its chemical formula is O2NC6H4OP(O)Cl2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Nitrophenyl phosphorodichloridate with an assay of 98%. This product is typically supplied for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should 4-Nitrophenyl phosphorodichloridate be handled safely?
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4-Nitrophenyl phosphorodichloridate is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, face shields, chemical-resistant gloves, and respiratory protection (e.g., N100 respirator), is essential. Handle in a well-ventilated area, preferably a fume hood. Immediate medical attention is required in case of exposure.
How is this chemical shipped and exported?
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4-Nitrophenyl phosphorodichloridate is shipped and exported under UN 3261, Hazard Class 8, Packing Group II. Tech Serve Solutions adheres to all international shipping regulations for hazardous materials.
How can I request a sample or quote?
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To request a sample or a quotation for 4-Nitrophenyl phosphorodichloridate, please contact our sales department through the website or by telephone. Our team will be pleased to assist you.
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