4-Nitrobenzenesulfonyl chloride
4-Nitrobenzenesulfonyl chloride (CAS: 98-74-8), with the chemical formula O2NC6H4SO2Cl and a molecular weight of 221.62 g/mol, is a key organic building block. This sulfonyl halide is instrumental in various chemical syntheses, including the preparation of complex coordination compounds and the derivatisation of amines and hydroxylamines. Tech Serve Solutions supplies this compound for laboratory research and chemical synthesis applications.
Synthesis of Coordination Compounds
4-Nitrobenzenesulfonyl chloride serves as a precursor in the synthesis of metal complexes, such as [Cu(bipy)2Cl](nbs), where it acts as the counter-ion (nbs = 4-nitrobenzenesulfonate).
Derivatisation of Hydroxylamines
It is employed in the preparation of hydroxylamines derived from sulfonamides like sulfadiazine and sulfamethoxazole, facilitating structural modifications.
Peptide Synthesis
4-Nitrobenzenesulfonyl chloride is utilised in solution-phase peptide synthesis through the formation of N-nosyl-α-amino acids, aiding in protecting group strategies.
| Molecular weight | 221.62 |
|---|---|
| Linear formula | O2NC6H4SO2Cl |
| Assay | ≥95.0% (AT) |
| Application | 4-Nitrobenzenesulfonyl chloride was used in the synthesis of • [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate)1• hydroxylamines of sulfadiazine and sulfamethoxazole2• solution phase peptide using N-nosyl-α-amino acids3. |
| Melting point | 66-70 °C(lit.)75-79 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Nitrobenzenesulfonyl chloride used for?
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4-Nitrobenzenesulfonyl chloride is primarily used as a building block in chemical synthesis, including the preparation of coordination compounds, derivatisation of hydroxylamines, and in solution-phase peptide synthesis.
What are the CAS number and chemical formula for 4-Nitrobenzenesulfonyl chloride?
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The CAS number for 4-Nitrobenzenesulfonyl chloride is 98-74-8, and its chemical formula is O2NC6H4SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Nitrobenzenesulfonyl chloride with an assay of ≥95.0% (AT). We do not represent this product as USP, BP, or EP grade.
How should 4-Nitrobenzenesulfonyl chloride be handled?
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4-Nitrobenzenesulfonyl chloride is classified as Danger with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including eyeshields, faceshields, and chemical-resistant gloves, must be worn. Ensure adequate ventilation and use a suitable respirator.
Is 4-Nitrobenzenesulfonyl chloride available for export?
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Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals like 4-Nitrobenzenesulfonyl chloride.
How can I request a sample or quote for 4-Nitrobenzenesulfonyl chloride?
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To request a sample or quote, please contact our sales team through the website or by phone, providing the product name and CAS number.
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