(4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine
(4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine (CAS 932710-63-9) is a high-purity phosphine ligand with a molecular weight of 265.37 g/mol. This compound is primarily utilised in catalysis, specifically in the preparation of palladium-based catalysts. Its structure makes it effective in various cross-coupling reactions, particularly involving aryl boronic acids and heteroaryl chlorides, facilitating complex organic synthesis in research and development.
- IUPAC
- A-taPhos,[4-(Dimethylamino)phenyl]bis(tert-butyl)phosphine
- Synonyms
- A-taPhos,[4-(Dimethylamino)phenyl]bis(tert-butyl)phosphine
Palladium Catalyst Preparation
This phosphine serves as a ligand for preparing palladium dichloride catalysts when treated with PdCl2(COD). These catalysts are crucial for facilitating complex chemical transformations.
Cross-Coupling Reactions
The ligand is effective in the cross-coupling of aryl boronic acids with heteroaryl chlorides. This application is vital for the synthesis of advanced organic molecules.
Organic Synthesis
As a key component in catalytic systems, (4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine supports various synthetic routes in pharmaceutical and fine chemical development.
| Molecular weight | 265.37 |
|---|---|
| Empirical formula | C16H28NP |
| Assay | 95% |
| Application | Ligand used to prepare a palladium dichloride catalyst (678740) on treatment with PdCl2(COD). The catalyst effectively cross-couples aryl boronic acids with heteroaryl chlorides.1 |
| Melting point | 57-61 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine used for?
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It is primarily used as a ligand in the preparation of palladium catalysts for cross-coupling reactions, such as the coupling of aryl boronic acids with heteroaryl chlorides.
What is the CAS number and formula for this compound?
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The CAS number is 932710-63-9 and the empirical formula (Hill notation) is C16H28NP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with a minimum purity of 95%. We do not represent this product as USP, BP, or EP grade.
How should (4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine be handled?
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This compound causes severe skin burns and eye damage (H314). Wear protective gloves, protective clothing, eye protection, and face protection (P280). If in eyes, rinse cautiously with water for several minutes; remove contact lenses, if present and easy to do. Continue rinsing (P305 + P351 + P338). Immediately call a poison centre or doctor (P310).
How is this chemical packed and shipped?
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Tech Serve Solutions exports chemicals globally, adhering to all necessary safety and regulatory standards for packaging and shipment.
How can I request a sample or quote for this product?
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Please contact our sales team via the website or phone to request a sample or a quotation for (4-(N,N-Dimethylamino)phenyl)di-tert-butyl phosphine.
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