4-Methyl-3-thiopheneboronic acid pinacol ester
4-Methyl-3-thiopheneboronic acid pinacol ester (CAS: 476620-20-9; Formula: C11H17BO2S) is a stable organoboron compound with a molecular weight of 224.13 g/mol. This thiophene derivative serves as a versatile building block in organic synthesis, particularly in cross-coupling reactions for the construction of complex organic molecules. It is widely utilised in medicinal chemistry and materials science research.
- IUPAC
- 4,4,5,5-Tetramethyl-2-(4-methyl-3-thienyl)-1,3,2-dioxaborolane,4,4,5,5-Tetramethyl-2-(4-methylthien-3-yl)-1,3,2-dioxaborolane,4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene
- Synonyms
- 4,4,5,5-Tetramethyl-2-(4-methyl-3-thienyl)-1,3,2-dioxaborolane4,4,5,5-Tetramethyl-2-(4-methylthien-3-yl)-1,3,2-dioxaborolane4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene
Organic Synthesis Building Block
This boronate ester is frequently employed in Suzuki-Miyaura cross-coupling reactions to introduce the 4-methyl-3-thienyl moiety into various organic scaffolds. It facilitates the formation of carbon-carbon bonds, crucial for constructing complex molecular architectures.
Medicinal Chemistry Intermediate
Its structural features make it a valuable intermediate in the synthesis of novel pharmaceutical candidates. The thiophene ring system is a common pharmacophore found in many biologically active compounds.
Materials Science Research
The compound can be used in the development of new organic materials, such as conjugated polymers or small molecules with specific electronic or optical properties, owing to the presence of the thiophene ring.
| Molecular weight | 224.13 |
|---|---|
| Empirical formula | C11H17BO2S |
| Assay | 96% |
| Boiling point | 72-75 °C/0.2-0.3 mmHg |
| Density | 1.031 g/mL at 25 °C |
| Refractive index | n20/D 1.5039 |
| Flash point | >110 °C / >230 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methyl-3-thiopheneboronic acid pinacol ester used for?
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4-Methyl-3-thiopheneboronic acid pinacol ester is primarily used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, and as an intermediate in medicinal chemistry and materials science research.
What are the CAS number and formula for 4-Methyl-3-thiopheneboronic acid pinacol ester?
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The CAS number is 476620-20-9 and the empirical formula is C11H17BO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methyl-3-thiopheneboronic acid pinacol ester with an assay of 96%. This product is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 4-Methyl-3-thiopheneboronic acid pinacol ester be handled?
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4-Methyl-3-thiopheneboronic acid pinacol ester is classified under WGK 2 in Germany, indicating it is hazardous to water. It has a high flash point (>110 °C), suggesting it is not highly flammable. Handle with appropriate personal protective equipment in a well-ventilated area.
Is this chemical exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-Methyl-3-thiopheneboronic acid pinacol ester.
How can I request a sample or quote?
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To request a sample or a quote for 4-Methyl-3-thiopheneboronic acid pinacol ester, please contact our sales team through the website or via direct enquiry.
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