4-Ethynylaniline
4-Ethynylaniline (CAS: 14235-81-5) is a crucial organic building block with the molecular formula HC≡CC₆H₄NH₂ and a molecular weight of 117.15 g/mol. This terminal alkyne featuring an amine group is primarily utilised in chemical synthesis, notably as a reactant in palladium-catalysed indole synthesis from nitroarenes. Its distinct structure makes it valuable for constructing complex organic molecules and in conjugation chemistry.
- IUPAC
- 1-Amino-4-ethynylbenzene,P-APAC
- Synonyms
- 1-Amino-4-ethynylbenzeneP-APAC
Organic Synthesis Intermediate
Serves as a key building block in the synthesis of various organic compounds. It is particularly noted for its role in the preparation of indoles from nitroarenes using palladium catalysis.
Conjugation Chemistry
The terminal alkyne functionality makes it suitable for click chemistry reactions, enabling the conjugation of molecules in chemical biology and materials science.
Research and Development
Utilised in academic and industrial research laboratories for the development of new synthetic methodologies and the creation of novel chemical entities.
| Molecular weight | 117.15 |
|---|---|
| Linear formula | HC≡CC6H4NH2 |
| Assay | 97% |
| Application | Used as an alkyne component in a synthesis of indoles from nitroarenes in the presence of a palladium-phenantroline catalyst.1 |
| Melting point | 98-102 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Ethynylaniline used for?
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4-Ethynylaniline is used as an alkyne component in the synthesis of indoles from nitroarenes, employing a palladium-phenantroline catalyst. It is also a valuable building block in organic synthesis and conjugation chemistry.
What is the CAS number and formula for 4-Ethynylaniline?
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The CAS number is 14235-81-5 and the linear formula is HC≡CC₆H₄NH₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Ethynylaniline with a minimum assay of 97%. This product is intended for research and technical use and is not supplied as USP, BP, EP, or pharmaceutical grade.
How should 4-Ethynylaniline be handled safely?
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4-Ethynylaniline is a Warning substance (GHS07) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be worn. Ensure good ventilation and avoid dust formation. Refer to the Safety Data Sheet for comprehensive handling information.
How is 4-Ethynylaniline packed and shipped?
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4-Ethynylaniline is carefully packed according to international shipping regulations to ensure safe transit. As a global supplier, Tech Serve Solutions exports this chemical worldwide.
How can I request a sample or quote for 4-Ethynylaniline?
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To request a sample or a quote for 4-Ethynylaniline, please contact our sales department via the website or by phone. Provide your details and the quantity required for prompt assistance.
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