α,4-Dichloroanisole
α,4-Dichloroanisole (CAS: 21151-56-4) is a chlorinated anisole derivative with the molecular formula ClC6H4OCH2Cl and a molecular weight of 177.03 g/mol. This compound serves as a valuable intermediate in chemical synthesis, particularly within organic chemistry research and development. Its specific structure lends itself to various derivatization and protection strategies in multi-step synthetic processes, making it a useful reagent for advanced chemical applications.
- Synonyms
- 1-chloro-4-(chloromethoxy)benzene

Organic Synthesis Intermediate
Utilised as a building block in the synthesis of more complex organic molecules. Its functional groups allow for diverse chemical transformations.
Protecting Group Chemistry
Can be employed in strategies requiring the temporary protection of certain functional groups during synthetic routes. This aids in directing reactions to specific sites within a molecule.
Derivatization Reagent
Serves as a reagent for introducing specific structural motifs into target compounds. This is common in the development of novel materials or pharmaceutical candidates.
| Molecular weight | 177.03 |
|---|---|
| Linear formula | ClC6H4OCH2Cl |
| Assay | 97% |
| Boiling point | 120-124 °C/18 mmHg(lit.) |
| Refractive index | n20/D 1.552(lit.) |
| Storage temperature | 2-8°C |
| Melting point | 29-30 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is α,4-Dichloroanisole primarily used for?
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α,4-Dichloroanisole (CAS: 21151-56-4) is primarily used as an intermediate in organic synthesis, particularly for protection and derivatization strategies in the development of more complex chemical entities.
What are the CAS number and chemical formula for α,4-Dichloroanisole?
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The CAS number for α,4-Dichloroanisole is 21151-56-4, and its linear formula is ClC6H4OCH2Cl.
What grade and purity does Tech Serve Solutions supply for α,4-Dichloroanisole?
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Tech Serve Solutions supplies α,4-Dichloroanisole with a minimum purity of 97%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
What are the key safety concerns when handling α,4-Dichloroanisole?
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α,4-Dichloroanisole is classified with GHS07 symbol and a Warning signal word. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be worn. Handle in a well-ventilated area.
How is α,4-Dichloroanisole typically stored and shipped?
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α,4-Dichloroanisole should be stored at temperatures between 2-8°C. TSS exports chemicals globally, adhering to all relevant shipping regulations.
How can I request a quote or sample for α,4-Dichloroanisole?
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To request a quote or a sample of α,4-Dichloroanisole, please use the contact form on our website or reach out to our sales team directly.
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