4-(Chloromethyl)benzoyl chloride
4-(Chloromethyl)benzoyl chloride (CAS: 876-08-4), with the linear formula ClCH2C6H4COCl and a molecular weight of 189.04 g/mol, is a valuable organic building block. It functions as an acid halide and carbonyl compound, crucial in various synthetic pathways. Notably, it has been employed as an initiator for atom transfer radical polymerization and as a key intermediate in the synthesis of pharmaceuticals, including anticancer agents.
Polymer Synthesis
Utilised as an atom transfer radical polymerization (ATRP) initiator for creating polymer brushes, such as polyacrylamide (PAAm) chains, on surfaces like silicon wafers.
Pharmaceutical Intermediate
Serves as a critical building block in the synthesis of active pharmaceutical ingredients, exemplified by its use in the microwave-assisted synthesis of the anticancer agent imatinib.
Organic Synthesis Reagent
Functions as a versatile acid halide in organic chemistry, enabling the introduction of the 4-(chloromethyl)benzoyl moiety into diverse molecular structures.
| Molecular weight | 189.04 |
|---|---|
| Linear formula | ClCH2C6H4COCl |
| Assay | 97% |
| Boiling point | 126-128 °C/6 mmHg(lit.) |
| Application | 4-(Chloromethyl)benzoyl chloride was used as an atom transfer radical polymerization (ATRP) initiator in the growth of polyacrylamide (PAAm) brushes from silicon wafers1. It was also used as a building block in a microwave-assisted, solid-phase synthesis of imatinib, an anticancer agent2. |
| Melting point | 30-32 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 93 °C / 199.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 23-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Chloromethyl)benzoyl chloride used for?
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4-(Chloromethyl)benzoyl chloride is used in organic synthesis, notably as an atom transfer radical polymerization (ATRP) initiator and as a building block in pharmaceutical synthesis, including for anticancer agents.
What is the CAS number and chemical formula for 4-(Chloromethyl)benzoyl chloride?
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The CAS number is 876-08-4, and the linear chemical formula is ClCH2C6H4COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Chloromethyl)benzoyl chloride with a minimum assay of 97%. This is a technical/research grade, and TSS does not represent it as USP, BP, or EP grade.
How should 4-(Chloromethyl)benzoyl chloride be handled safely?
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4-(Chloromethyl)benzoyl chloride is a Danger hazard, causing severe skin burns and eye damage (H314) and potentially irritating the respiratory tract (H335). Handle with appropriate personal protective equipment, including full-face respirators, chemical-resistant gloves, and eye protection, in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling instructions.
Does Tech Serve Solutions export 4-(Chloromethyl)benzoyl chloride?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-(Chloromethyl)benzoyl chloride.
How can I request a sample or quote for 4-(Chloromethyl)benzoyl chloride?
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To request a sample or obtain a quotation for 4-(Chloromethyl)benzoyl chloride, please contact our sales department via the website or direct telephone.
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