4-Chloromercuribenzoic acid
4-Chloromercuribenzoic acid (CAS 59-85-8) is an organomercury compound with a molecular weight of 357.16 g/mol. It serves as a potent inhibitor of enzymes that depend on unmodified cysteine residues, such as adenylyl cyclase. Its primary applications lie in chemical synthesis and molecular biology, particularly for protein sequencing and structural analysis where precise enzyme modification is required.
- IUPAC
- 4-(Chloromercurio)benzoic acid,4-(Hydroxymercuri)benzoic acid
Enzyme Inhibition
Used to selectively inhibit enzymes requiring free cysteine residues for activity, such as adenylyl cyclase. This allows for focused study of biochemical pathways.
Protein Sequencing
A key reagent in protein sequencing protocols. It modifies cysteine residues, aiding in peptide mapping and structural determination.
Chemical Synthesis
Employed as a reagent in organic synthesis, particularly in reactions involving organometallic intermediates or specific functional group modifications.
Proteomics Research
Utilised in proteomics to probe protein structure and function by modifying specific amino acid residues, contributing to a deeper understanding of cellular processes.
| Molecular weight | 357.16 |
|---|---|
| Linear formula | ClHgC6H4CO2H |
| Application | Can be used to inhibit some enzymes that require unmodified cysteine residues (e.g., adenylyl cyclase). |
| Melting point | 287 °C (dec.)(lit.) |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
- H373May cause damage to organs through prolonged exposure
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2025 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+,N |
| Risk statements (R) | 26/27/28-33-50/53 |
| Safety statements (S) | 13-28-36-45-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Description | cysteine active site modifier |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloromercuribenzoic acid primarily used for?
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4-Chloromercuribenzoic acid is primarily used as an inhibitor of enzymes that require unmodified cysteine residues, such as adenylyl cyclase, and as a reagent in protein sequencing and structural analysis.
What is the CAS number and formula for 4-Chloromercuribenzoic acid?
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The CAS number is 59-85-8 and the linear formula is ClHgC 6 4 CO 2 H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloromercuribenzoic acid typically as a research or technical grade. We do not represent this product as USP, BP, or EP grade unless explicitly stated in the product specifications.
How should 4-Chloromercuribenzoic acid be handled safely?
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4-Chloromercuribenzoic acid is a Danger substance (GHS06, GHS08, GHS09) requiring stringent safety precautions. It is acutely toxic if swallowed, in contact with skin, or if inhaled, may cause damage to organs through prolonged or repeated exposure, and is very toxic to aquatic life with long lasting effects. Appropriate personal protective equipment, including a dust mask (N95), eyeshields, gloves, and a P2 respirator cartridge, must be used in a well-ventilated area. Avoid release to the environment.
How is 4-Chloromercuribenzoic acid packed, shipped, and exported?
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As per UN 2025 classification, 4-Chloromercuribenzoic acid is packed and shipped according to regulations for toxic substances. Tech Serve Solutions is an experienced global exporter of fine chemicals.
How can I request a sample or quote for 4-Chloromercuribenzoic acid?
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Please contact our sales department via phone or email to request a sample or a quotation for 4-Chloromercuribenzoic acid, providing your specific requirements.
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