4′-Chlorobiphenyl-4-sulfonyl chloride
4′-Chlorobiphenyl-4-sulfonyl chloride (CAS: 20443-74-7), with the molecular formula C12H8Cl2O2S and a molecular weight of 287.16 g/mol, is a reactive organic building block. As a sulfonyl halide, it is primarily utilised in organic synthesis for introducing the 4′-chlorobiphenyl-4-sulfonyl group into various molecules. Its applications span research and development, particularly in the creation of novel chemical entities for pharmaceutical and materials science exploration.

Organic Synthesis Intermediate
This compound serves as a key intermediate in the synthesis of more complex organic molecules. Its sulfonyl chloride functionality readily reacts with nucleophiles, enabling the formation of sulfonamides, sulfonates, and other sulfur-containing derivatives.
Pharmaceutical Research
It is employed in the development of new drug candidates. The biphenyl moiety, coupled with the sulfonyl group, can be incorporated into structures to explore potential biological activities and structure-activity relationships.
Materials Science
The unique structural features of 4′-Chlorobiphenyl-4-sulfonyl chloride make it a potential building block for functional materials, such as polymers or dyes, where specific electronic or structural properties are desired.
| Molecular weight | 287.16 |
|---|---|
| Empirical formula | C12H8Cl2O2S |
| Assay | 97% |
| Melting point | 108-110 °C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Transport (UN / ADR) | UN 3261 8 / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4′-Chlorobiphenyl-4-sulfonyl chloride used for?
+
4′-Chlorobiphenyl-4-sulfonyl chloride is primarily used as a building block in organic synthesis for creating new chemical entities, particularly in pharmaceutical research and materials science, by introducing the 4′-chlorobiphenyl-4-sulfonyl group.
What is the CAS number and formula for 4′-Chlorobiphenyl-4-sulfonyl chloride?
+
The CAS number is 20443-74-7 and the empirical formula is C12H8Cl2O2S.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 4′-Chlorobiphenyl-4-sulfonyl chloride with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 4′-Chlorobiphenyl-4-sulfonyl chloride be handled?
+
This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). It reacts violently with water. Handle with appropriate personal protective equipment (P280) in a well-ventilated area. Avoid contact with water (Supplemental Hazard Statement: Reacts violently with water).
Is 4′-Chlorobiphenyl-4-sulfonyl chloride suitable for export?
+
Yes, Tech Serve Solutions can export 4′-Chlorobiphenyl-4-sulfonyl chloride. It is classified under UN 3261, 8/PGII.
How can I request a quote or sample of 4′-Chlorobiphenyl-4-sulfonyl chloride?
+
To request a quote or sample, please use the contact form on our website or contact our sales department directly, referencing the product name and CAS number (20443-74-7).
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis