4-Chlorobenzoyl chloride
4-Chlorobenzoyl chloride (CAS: 122-01-0), a reactive acyl chloride with the molecular formula ClC6H4COCl and a molecular weight of 175.01 g/mol, serves as a crucial intermediate in organic synthesis. This compound is essential for introducing the 4-chlorobenzoyl group into various molecules. Its primary applications lie in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals, leveraging its reactivity for chemical transformations.
Synthesis of 4-Chlorobenzoyl CoA
4-Chlorobenzoyl chloride is employed in biochemical research to synthesize 4-chlorobenzoyl CoA. This reaction involves the coupling of 4-chlorobenzoyl chloride with coenzyme A (CoA) in a potassium bicarbonate buffer solution.
Intermediate in Organic Synthesis
As a versatile building block, it is widely used in the chemical industry for producing a range of organic compounds. Its acyl chloride functionality readily participates in acylation reactions, making it valuable for creating complex molecular structures.
Pharmaceutical & Agrochemical Precursor
The compound acts as a key intermediate in the manufacturing pathways for various pharmaceutical agents and agrochemical products. Its incorporation is vital for the development of active ingredients with specific biological activities.
| Molecular weight | 175.01 |
|---|---|
| Linear formula | ClC6H4COCl |
| Assay | 95% |
| Boiling point | 102-104 °C/11 mmHg(lit.) |
| Density | 1.365 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.578(lit.) |
| Application | 4-Chlorobenzoyl chloride was used to synthesize 4-chlorobenzoyl CoA by reacting it with CoA in KHCO3 buffer1. |
| Melting point | 11-14 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 105 °C / 221 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chlorobenzoyl chloride used for?
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4-Chlorobenzoyl chloride is primarily used as an intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and for specific biochemical reactions such as the synthesis of 4-chlorobenzoyl CoA.
What are the CAS number and formula for 4-Chlorobenzoyl chloride?
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The CAS number for 4-Chlorobenzoyl chloride is 122-01-0, and its linear formula is ClC6H4COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chlorobenzoyl chloride with a minimum assay of 95%. We do not represent this product as USP, BP, or EP grade; it is supplied for research and industrial applications.
How should 4-Chlorobenzoyl chloride be handled?
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4-Chlorobenzoyl chloride is a corrosive substance (H314) and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including gloves, goggles, a faceshield, and a suitable respirator. Ensure adequate ventilation and avoid contact with skin, eyes, and clothing.
How is 4-Chlorobenzoyl chloride packed, shipped, and exported?
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4-Chlorobenzoyl chloride is classified under UN 3265, Class 8, Packing Group II. It is securely packaged and expertly handled for domestic and international export by TSS in compliance with all relevant transport regulations.
How can I request a sample or quote for 4-Chlorobenzoyl chloride?
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To request a sample or obtain a quotation for 4-Chlorobenzoyl chloride, please contact our sales team via the website or direct email, providing your specific requirements.
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