4-Chloro-3-nitroanisole
4-Chloro-3-nitroanisole (CAS: 10298-80-3) is an organic compound with the formula ClC6H3(NO2)OCH3. This chemical, with a molecular weight of 187.58 g/mol, serves as a valuable building block in organic synthesis. Its primary application lies in the preparation of complex molecules, particularly within research and development settings in the chemical and pharmaceutical industries.
- IUPAC
- 1-Chloro-4-methoxy-2-nitrobenzene
- Synonyms
- 1-Chloro-4-methoxy-2-nitrobenzene

Synthesis of Chromone Derivatives
4-Chloro-3-nitroanisole is utilised as a precursor in the synthesis of various derivatives of 7-methanesulfonylamino-6-phenoxychromone. It is involved in modifications at both the pyrone and phenoxy rings of the target molecules.
Organic Synthesis Intermediate
As a substituted nitroanisole, it functions as a versatile intermediate in the construction of more complex organic structures. Its reactive chloro and nitro groups allow for diverse chemical transformations.
Research and Development
This compound is employed in laboratory settings for research purposes, enabling the exploration of new chemical pathways and the development of novel compounds.
| Molecular weight | 187.58 |
|---|---|
| Linear formula | ClC6H3(NO2)OCH3 |
| Assay | 98% |
| Application | 4-chloro-3-nitroanisole is used to synthesize a group of derivatives of 7-methanesulfonylamino-6-phenoxychromone at the pyrone and phenoxy rings. |
| Melting point | 41-43 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-3-nitroanisole used for?
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4-Chloro-3-nitroanisole is used as a building block in organic synthesis, notably for the preparation of derivatives of 7-methanesulfonylamino-6-phenoxychromone.
What is the CAS number and chemical formula for 4-Chloro-3-nitroanisole?
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The CAS number is 10298-80-3 and the chemical formula is ClC6H3(NO2)OCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-3-nitroanisole with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 4-Chloro-3-nitroanisole be handled safely?
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Based on its GHS classification, 4-Chloro-3-nitroanisole is an irritant. Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be worn. Ensure adequate ventilation to avoid inhalation.
Can Tech Serve Solutions export 4-Chloro-3-nitroanisole?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 4-Chloro-3-nitroanisole.
How can I request a quote or sample?
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Please contact our sales department via the website or telephone to request a quote or sample of 4-Chloro-3-nitroanisole.
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