4′-Chloro-3′-nitroacetophenone
4′-Chloro-3′-nitroacetophenone (CAS: 5465-65-6) is an organic compound with the linear formula ClC₆H₃(NO₂)COCH₃ and a molecular weight of 199.59 g/mol. This chemical serves as a crucial building block in organic synthesis. It is primarily utilized as a starting reagent in the preparation of more complex molecules, including quinoxaline derivatives, contributing to advancements in chemical research and development.

Synthesis of Quinoxaline Derivatives
4′-Chloro-3′-nitroacetophenone is employed as a key starting material in the synthesis of 6- and 7-acetyl-3-methyl-2-quinoxalinecarboxamide 1,4-dioxides. This application highlights its utility in constructing complex heterocyclic systems.
Organic Synthesis Building Block
As a versatile building block, this compound is valuable for introducing specific functional groups into organic molecules. Its structure allows for further chemical modifications, making it useful in multi-step synthetic routes.
Chemical Research and Development
Researchers utilize 4′-Chloro-3′-nitroacetophenone in laboratory settings for exploring new synthetic pathways and developing novel chemical entities. Its availability supports innovation in various chemical disciplines.
| Molecular weight | 199.59 |
|---|---|
| Linear formula | ClC6H3(NO2)COCH3 |
| Assay | 99% |
| Application | 4′-Chloro-3′-nitroacetophenone was used to prepare starting reagent for the synthesis of 6- and 7-acetyl-3-methyl-2-quinoxalinecarboxamide1,4-dioxides1. |
| Melting point | 99-101 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4′-Chloro-3′-nitroacetophenone used for?
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4′-Chloro-3′-nitroacetophenone is primarily used as a building block in organic synthesis. It serves as a starting reagent for preparing compounds like quinoxaline derivatives, contributing to chemical research and development.
What are the CAS number and chemical formula for 4′-Chloro-3′-nitroacetophenone?
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The CAS number for 4′-Chloro-3′-nitroacetophenone is 5465-65-6, and its linear formula is ClC₆H₃(NO₂)COCH₃.
What grade and purity does Tech Serve Solutions supply for 4′-Chloro-3′-nitroacetophenone?
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Tech Serve Solutions supplies 4′-Chloro-3′-nitroacetophenone with an assay of 99%. We do not represent this product as meeting USP, BP, EP, or any pharmacopoeia standards.
What are the main safety hazards associated with 4′-Chloro-3′-nitroacetophenone?
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4′-Chloro-3′-nitroacetophenone is classified with a Warning signal word. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used.
How is 4′-Chloro-3′-nitroacetophenone packed, shipped, and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, handles the packing, shipping, and international export of 4′-Chloro-3′-nitroacetophenone in compliance with all relevant regulations.
How can I request a sample or quote for 4′-Chloro-3′-nitroacetophenone?
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To request a sample or a quote for 4′-Chloro-3′-nitroacetophenone, please contact our sales team through the website or via direct inquiry.
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