4-(Boc-aminomethyl)phenyl isothiocyanate
4-(Boc-aminomethyl)phenyl isothiocyanate (CAS 89631-74-3), with the molecular formula C13H16N2O2S and a molecular weight of 264.34 g/mol, is a versatile reagent. It is primarily utilised in molecular biology and protein chemistry for labelling and modification. Its isothiocyanate group readily reacts with primary amines, making it invaluable for applications such as protein sequencing and structural analysis.
- IUPAC
- 4-(N-tert-Butoxycarbonylaminomethyl)phenyl isothiocyanate,tert-Butyl N-(4-isothiocyanatophenylmethyl)carbamate,BAMPITC,N-Boc-4-isothiocyanatobenzylamine
- Synonyms
- 4-(N-tert-Butoxycarbonylaminomethyl)phenyl isothiocyanatetert-Butyl N-(4-isothiocyanatophenylmethyl)carbamateBAMPITCN-Boc-4-isothiocyanatobenzylamine
Protein Sequencing and Edman Degradation
This compound serves as a reagent in protein sequencing, particularly in modified Edman degradation protocols. The isothiocyanate moiety reacts with the N-terminal amino group of peptides or proteins.
Bioconjugation and Labelling
4-(Boc-aminomethyl)phenyl isothiocyanate is employed for conjugating molecules to proteins or other biomolecules. Its reactivity allows for the attachment of labels or tags for research purposes.
Proteomics Research
Within proteomics, this chemical is used in the structural analysis and modification of proteins. It aids in characterising protein functions and interactions.
Synthesis of Modified Peptides
It can be used as a building block in the synthesis of modified peptides. The Boc-protected amine offers a handle for further functionalization after the isothiocyanate reaction.
| Molecular weight | 264.34 |
|---|---|
| Empirical formula | C13H16N2O2S |
| Assay | ≥98.0% (HPLC) |
| Melting point | 111-113 °C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38-42 |
| Safety statements (S) | 22-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Boc-aminomethyl)phenyl isothiocyanate used for?
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This compound is primarily used in molecular biology and protein chemistry for applications such as protein sequencing, bioconjugation, and structural analysis. Its isothiocyanate group reacts with primary amines, enabling its use as a labelling and modification reagent.
What are the CAS number and molecular formula?
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The CAS number for 4-(Boc-aminomethyl)phenyl isothiocyanate is 89631-74-3, and its molecular formula is C13H16N2O2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Boc-aminomethyl)phenyl isothiocyanate with an assay of ≥98.0% (HPLC). We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
How should this chemical be handled safely?
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This product is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation. It may also cause respiratory irritation and an allergic skin reaction. Handle with appropriate personal protective equipment, including a dust mask (type N95), eyeshields, faceshields, and gloves, in a well-ventilated area. Avoid breathing dust.
Is this chemical available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-(Boc-aminomethyl)phenyl isothiocyanate.
How can I request a quote or sample?
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To request a quote or sample for 4-(Boc-aminomethyl)phenyl isothiocyanate, please contact our sales department through the website or call us directly.
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