4-Biphenylzinc bromide solution
4-Biphenylzinc bromide solution (CAS 312693-44-0) with the linear formula C6H5C6H4ZnBr and a molecular weight of 298.49 g/mol, is a key organozinc reagent. Supplied as a 0.5 M solution in THF, it offers excellent reactivity. This compound is primarily utilised in advanced organic synthesis, particularly for cross-coupling reactions, enabling the formation of complex carbon-carbon bonds in pharmaceutical and fine chemical development.
Cross-Coupling Reactions
4-Biphenylzinc bromide is extensively used in Suzuki-Miyaura and Negishi cross-coupling reactions. It serves as an effective nucleophile for introducing the biphenyl moiety onto various organic substrates, facilitating the synthesis of complex molecules.
Organic Synthesis Intermediate
As a versatile organozinc halide, it acts as a crucial intermediate in multi-step synthetic pathways. Its controlled reactivity allows for selective functionalisation in the preparation of advanced materials and pharmaceutical candidates.
Formation of Biaryls
This reagent is instrumental in constructing biaryl structures, which are common motifs in many biologically active compounds and organic electronic materials. The biphenyl group can be precisely installed using this zinc reagent.
| Molecular weight | 298.49 |
|---|---|
| Linear formula | C6H5C6H4ZnBr |
| Boiling point | 65 °C |
| Density | 0.994 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2056 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Biphenylzinc bromide solution used for?
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4-Biphenylzinc bromide solution is primarily used in organic synthesis, particularly for cross-coupling reactions like Suzuki-Miyaura and Negishi couplings, to introduce the biphenyl group and form C-C bonds.
What are the CAS number and formula for 4-Biphenylzinc bromide solution?
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The CAS number is 312693-44-0, and the linear formula is C6H5C6H4ZnBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Biphenylzinc bromide solution at a concentration of 0.5 M in THF. We do not specify pharmacopoeia grades unless explicitly stated in the product data.
What are the safety and handling considerations for this product?
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This product is highly flammable (H225) and can form explosive peroxides. It causes serious eye irritation (H319) and may cause respiratory irritation (H335). It is also suspected of causing cancer (H351). Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources.
How is 4-Biphenylzinc bromide solution packed, shipped, and exported?
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4-Biphenylzinc bromide solution is packed according to UN 2056, Class 3, Packing Group II regulations, suitable for safe international shipment.
How can I request a sample or quote for 4-Biphenylzinc bromide solution?
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To request a sample or a quotation, please contact our sales department through the website or by phone, providing the product name and CAS number.
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