4,5-Dimethoxy-2-nitrobenzyl chloroformate
4,5-Dimethoxy-2-nitrobenzyl chloroformate (CAS: 42855-00-5) is a specialised reagent with the molecular formula ClCO2CH2C6H2(OCH3)2NO2 and a molecular weight of 275.64 g/mol. It serves as a key intermediate in organic synthesis, particularly for the introduction of protecting groups onto amine functionalities. This compound is widely employed in peptide chemistry and chemical biology due to its utility in selective protection and derivatisation strategies.
- IUPAC
- 6-Nitroveratryloxycarbonyl chloride,6-Nitroveratryl chloroformate,NVOC chloride,NVOC-Cl
- Synonyms
- 6-Nitroveratryloxycarbonyl chloride6-Nitroveratryl chloroformateNVOC chlorideNVOC-Cl
Amine Protection
4,5-Dimethoxy-2-nitrobenzyl chloroformate is extensively used for the protection of amine groups in complex organic molecules. Its specific structure allows for orthogonal deprotection strategies in multi-step synthesis.
Peptide Synthesis
This chloroformate derivative is a valuable reagent in peptide chemistry for the selective protection of amino acid residues. It facilitates controlled peptide chain elongation.
Chemical Biology
In chemical biology, it is applied in the modification and functionalisation of biomolecules. The nitrobenzyl moiety can offer unique photoreactivity or other specific properties upon deprotection.
Organic Synthesis
As a versatile synthetic reagent, it aids in the preparation of various organic compounds by introducing the dimethoxy-nitrobenzyl protecting group, which can be selectively removed under specific conditions.
| Molecular weight | 275.64 |
|---|---|
| Linear formula | ClCO2CH2C6H2(OCH3)2NO2 |
| Assay | ≥97.0% (AT) |
| Storage temperature | 2-8°C |
| Melting point | 125 °C (dec.)(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4,5-Dimethoxy-2-nitrobenzyl chloroformate used for?
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4,5-Dimethoxy-2-nitrobenzyl chloroformate is primarily used as a protecting group reagent, particularly for amines, in organic synthesis, peptide chemistry, and chemical biology.
What is the CAS number and molecular formula for 4,5-Dimethoxy-2-nitrobenzyl chloroformate?
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The CAS number is 42855-00-5, and the molecular formula is ClCO2CH2C6H2(OCH3)2NO2.
What grade and purity does Tech Serve Solutions supply for 4,5-Dimethoxy-2-nitrobenzyl chloroformate?
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Tech Serve Solutions supplies this product with an assay of ≥97.0% (AT). We do not represent it as USP, BP, or EP grade.
How should 4,5-Dimethoxy-2-nitrobenzyl chloroformate be handled and stored?
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This compound is corrosive and can cause severe skin burns and eye damage (H314). It should be handled with appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection. Store at 2-8°C.
Is 4,5-Dimethoxy-2-nitrobenzyl chloroformate regulated or scheduled?
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The provided data does not indicate that this compound is a controlled substance. However, users should always verify local regulations.
How can I request a quote or sample for 4,5-Dimethoxy-2-nitrobenzyl chloroformate?
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Please contact the Tech Serve Solutions sales team via our website or direct inquiry to request a quote or sample of 4,5-Dimethoxy-2-nitrobenzyl chloroformate.
How is 4,5-Dimethoxy-2-nitrobenzyl chloroformate typically shipped?
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It is shipped as UN 3261, Class 8, Packing Group II, indicating it is a corrosive material requiring specialised transport.
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