4-(2-Iodoacetamido)-TEMPO
4-(2-Iodoacetamido)-TEMPO (CAS: 25713-24-0), with the molecular formula C11H20IN2O2 and a molecular weight of 339.19 g/mol, is a stable radical compound. It functions as a spin label, primarily utilised in biochemical research to investigate binding sites and evaluate the alkylation of specific amino acid residues in proteins. Its unique radical nature also lends itself to applications in chemical synthesis and electron spin resonance spectroscopy.
- IUPAC
- 4-(2-Iodoacetamido)-2,2,6,6-tetramethyl-1-piperidinyloxy, free radical,4-(2-Iodoacetamido)-2,2,6,6-tetramethylpiperidine 1-oxyl
- Synonyms
- 4-(2-Iodoacetamido)-2,2,6,6-tetramethyl-1-piperidinyloxy, free radical4-(2-Iodoacetamido)-2,2,6,6-tetramethylpiperidine 1-oxyl
Biochemical Research
Serves as a spin label to probe protein structures and interactions, notably used in studies of enzyme binding sites, such as phosphoenolpyruvate carboxykinase and GTP. It aids in evaluating the alkylation of specific cysteine residues (SH1 and SH2) in proteins like myosin.
Electron Spin Resonance (ESR/EPR) Spectroscopy
Its stable radical nature makes it valuable for ESR/EPR spectroscopy, enabling studies of radical dynamics and environments. It can be employed as a spin probe or spin label in various biological and chemical systems.
Chemical Synthesis
Utilised as a synthetic reagent in organic chemistry, leveraging its reactive iodoacetamide group for covalent modification of target molecules. It is also a derivative of the versatile TEMPO radical.
| Molecular weight | 339.19 |
|---|---|
| Empirical formula | C11H20IN2O2 |
| Storage temperature | 2-8°C |
| Application | Spin label used to investigate the binding site of phosphoenolpyruvate caboxykinase and GTP, and to evaluate the alkylation of SH1 and SH2 of myosin. |
| Melting point | 114-117 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(2-Iodoacetamido)-TEMPO used for?
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4-(2-Iodoacetamido)-TEMPO is primarily used as a spin label in biochemical research to investigate protein binding sites and evaluate the alkylation of specific amino acid residues. It is also applicable in Electron Spin Resonance (ESR/EPR) spectroscopy and as a synthetic reagent.
What are the CAS number and formula for 4-(2-Iodoacetamido)-TEMPO?
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The CAS number is 25713-24-0, and the empirical formula is C11H20IN2O2.
What grade and purity does Tech Serve Solutions supply for 4-(2-Iodoacetamido)-TEMPO?
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Tech Serve Solutions supplies 4-(2-Iodoacetamido)-TEMPO for research and laboratory use. The specific assay and purity are available on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should 4-(2-Iodoacetamido)-TEMPO be handled safely?
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4-(2-Iodoacetamido)-TEMPO is classified with GHS07 symbol and a 'Warning' signal word. It carries hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection if dust is generated. Ensure adequate ventilation.
How is 4-(2-Iodoacetamido)-TEMPO packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports fine chemicals, including 4-(2-Iodoacetamido)-TEMPO, adhering to all relevant international shipping regulations for hazardous materials. Specific packaging details depend on order size and destination.
How can I request a sample or quote for 4-(2-Iodoacetamido)-TEMPO?
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To request a sample or quote for 4-(2-Iodoacetamido)-TEMPO, please contact our sales team via the website or email, providing your contact details and the quantity required.
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