3-Trimethylsiloxy-1-propyne
3-Trimethylsiloxy-1-propyne (CAS 5582-62-7) is an organosilicon compound with the formula HC≡CCH₂OSi(CH₃)₃ and a molecular weight of 128.24 g/mol. This terminal alkyne features a trimethylsilyl protecting group on the hydroxyl functionality of propargyl alcohol. It serves as a valuable building block in organic synthesis and chemical research, offering a masked alkyne moiety for various synthetic transformations.
- IUPAC
- (Propargyloxy)trimethylsilane,O-(Trimethylsilyl)propargyl alcohol,Trimethyl(2-propynyloxy)silane,Trimethyl(propargyloxy)silane
- Synonyms
- (Propargyloxy)trimethylsilaneO-(Trimethylsilyl)propargyl alcoholTrimethyl(2-propynyloxy)silaneTrimethyl(propargyloxy)silane

Organic Synthesis
Serves as a versatile building block in organic synthesis due to its protected alkyne functionality. It can be used in click chemistry reactions or other alkyne-based transformations after deprotection.
Chemical Research
Utilised in academic and industrial research laboratories for the development of new synthetic methodologies and the preparation of complex organic molecules. Its structure allows for regioselective functionalisation.
Material Science
Potentially employed in the synthesis of novel polymers or functional materials where the alkyne group can be incorporated into a polymer backbone or side chain.
| Molecular weight | 128.24 |
|---|---|
| Linear formula | HC≡CCH2OSi(CH3)3 |
| Assay | 98% |
| Boiling point | 52 °C/85 mmHg(lit.) |
| Density | 0.835 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.408(lit.) |

Hazard statements
- H225Highly flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 8 °C / 46.4 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
| Safety statements (S) | 16-23-24/25 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Trimethylsiloxy-1-propyne used for?
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3-Trimethylsiloxy-1-propyne is primarily used as a building block in organic synthesis and for chemical research purposes. It allows for the introduction of a protected alkyne functionality in various synthetic routes.
What is the CAS number and molecular formula?
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The CAS number for 3-Trimethylsiloxy-1-propyne is 5582-62-7, and its molecular formula is HC≡CCH₂OSi(CH₃)₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Trimethylsiloxy-1-propyne with an assay of 98%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the safety considerations for handling 3-Trimethylsiloxy-1-propyne?
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3-Trimethylsiloxy-1-propyne is a highly flammable liquid and vapour (H225). It requires careful handling in a well-ventilated area, away from ignition sources. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, should be used. Refer to the Safety Data Sheet for comprehensive handling information.
How is 3-Trimethylsiloxy-1-propyne packed and shipped?
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3-Trimethylsiloxy-1-propyne is packed and shipped according to international regulations for hazardous materials, including UN 1993 classification. It is exported globally by Tech Serve Solutions, a specialist supplier established in 1998.
How can I request a quote or sample?
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To request a quote or sample of 3-Trimethylsiloxy-1-propyne, please contact our sales team through the website or by phone. Our dedicated team will assist you promptly with your inquiry.
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