3-Piperonylcyclobutanone
3-Piperonylcyclobutanone (CAS: 157020-88-7) is a fine chemical with the molecular formula C12H12O3 and a molecular weight of 204.22 g/mol. This compound serves as a valuable building block in organic synthesis. Its primary application lies in the chiral synthesis of various lignan lactones, contributing to the creation of complex natural product analogues and pharmaceutical intermediates.
- IUPAC
- 3-(1,3-Benzodioxol-5-ylmethyl)cyclobutanone,3-(3,4-Methylenedioxybenzyl)cyclobutanone
- Synonyms
- 3-(1,3-Benzodioxol-5-ylmethyl)cyclobutanone3-(3,4-Methylenedioxybenzyl)cyclobutanone

Chiral Synthesis of Lignan Lactones
3-Piperonylcyclobutanone is employed as a key reagent in the stereoselective synthesis of important lignan lactones. Specific examples include its use in the preparation of compounds such as (-)-hinokinin, (-)-deoxypodorhizone, (-)-isohibalactone, and (-)-savinin.
Heterocyclic Building Block
As a heterocyclic building block containing an oxygen atom and a cyclobutane ring fused with a piperonyl group, this compound offers unique structural features for diverse synthetic pathways in medicinal chemistry and materials science.
Organic Synthesis Intermediate
The molecule's structure makes it a versatile intermediate for constructing more complex organic molecules. Researchers can utilise its reactivity to introduce specific functionalities and chiral centres into target compounds.
| Molecular weight | 204.22 |
|---|---|
| Empirical formula | C12H12O3 |
| Assay | ≥98.0% (HPLC) |
| Application | 3-Piperonylcyclobutanone may be used as a reagent in the chiral synthesis of lignan lactones such as (-)-hinokinin, (-)-deoxypodorhizone, (-)-isohibalactone and (-)-savinin. |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Piperonylcyclobutanone used for?
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3-Piperonylcyclobutanone is primarily used as a reagent in the chiral synthesis of lignan lactones such as (-)-hinokinin, (-)-deoxypodorhizone, (-)-isohibalactone and (-)-savinin.
What are the CAS number and formula for 3-Piperonylcyclobutanone?
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The CAS number for 3-Piperonylcyclobutanone is 157020-88-7, and its molecular formula is C12H12O3.
What grade and purity does Tech Serve Solutions supply for 3-Piperonylcyclobutanone?
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Tech Serve Solutions supplies 3-Piperonylcyclobutanone with a purity of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP or other pharmacopoeial grades.
What are the safety and handling requirements for 3-Piperonylcyclobutanone?
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Based on available data, appropriate personal protective equipment includes eyeshields and gloves. The compound is classified under WGK Germany 3, indicating it is hazardous to water.
How is 3-Piperonylcyclobutanone packed and shipped?
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Tech Serve Solutions exports fine chemicals globally, adhering to all necessary regulations for safe packing and shipping of chemical reagents.
How can I request a quote or sample of 3-Piperonylcyclobutanone?
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To request a quote or a sample, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.
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