3-Methyl-1-butylboronic acid
3-Methyl-1-butylboronic acid (CAS 98139-72-1, C5H13BO2) is a boronic acid derivative with a molecular weight of 115.97. This organoboron compound serves as a valuable reactant in various organic synthesis applications. It is primarily utilised as a building block in cross-coupling reactions, enabling the formation of carbon-carbon bonds critical for constructing complex molecular architectures in pharmaceutical and chemical research.
- IUPAC
- Isopentylboronic acid
- Synonyms
- Isopentylboronic acid
Selective Cross-Coupling Reactions
3-Methyl-1-butylboronic acid acts as a nucleophilic partner in copper-promoted cross-coupling reactions with aromatic amines, facilitating the synthesis of novel amine derivatives. It is also employed in palladium-catalyzed Suzuki cross-coupling reactions with aryl halides for the preparation of alkylarenes.
Synthesis of Bioactive Compounds
This boronic acid derivative is a key intermediate in the synthesis of complex molecules, including indazole-based analogues that have demonstrated activity as sensitive Akt inhibitors. Its application aids in the development of potential therapeutic agents.
Organometallic Reagent
As an organometallic reagent, 3-Methyl-1-butylboronic acid is instrumental in various synthetic transformations. Its utility extends to the preparation of diverse organic structures, underscoring its importance in modern chemical synthesis.
| Molecular weight | 115.97 |
|---|---|
| Empirical formula | C5H13BO2 |
| Storage temperature | 2-8°C |
| Application | Reactant for:• Selective copper-promoted cross-coupling with aromatic amines1• Synthesis of indazole based analog sensitive Akt inhibitors2• Preparation of alkylarenes via tetraphosphine-palladium-catalyzed Suzuki cross-coupling with aryl halides3 |
| Melting point | 80-91 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Methyl-1-butylboronic acid used for?
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3-Methyl-1-butylboronic acid is used as a reactant in selective copper-promoted cross-coupling with aromatic amines, in the synthesis of indazole-based analog sensitive Akt inhibitors, and in the preparation of alkylarenes via palladium-catalyzed Suzuki cross-coupling with aryl halides.
What are the CAS number and formula for 3-Methyl-1-butylboronic acid?
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The CAS number for 3-Methyl-1-butylboronic acid is 98139-72-1, and its empirical formula is C5H13BO2.
What grade and purity does Tech Serve Solutions supply for 3-Methyl-1-butylboronic acid?
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Tech Serve Solutions supplies 3-Methyl-1-butylboronic acid as a research-grade chemical. The specific assay or purity is available upon request and is not guaranteed to meet USP, BP, or EP pharmacopoeial standards.
How should 3-Methyl-1-butylboronic acid be handled and stored?
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Handling 3-Methyl-1-butylboronic acid requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store the chemical at 2-8°C.
Does Tech Serve Solutions export 3-Methyl-1-butylboronic acid?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 3-Methyl-1-butylboronic acid.
How can I request a quote or sample of 3-Methyl-1-butylboronic acid?
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To request a quote or sample of 3-Methyl-1-butylboronic acid, please contact the Tech Serve Solutions sales team through our website or by phone.
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