3-Methoxyphenylzinc iodide solution
3-Methoxyphenylzinc iodide solution (CAS: 300825-30-3, Formula: CH3OC6H4ZnI, MW: 299.42) is a valuable organometallic reagent. Supplied at 0.5 M in THF, this solution is primarily utilised in organic synthesis for the introduction of the 3-methoxyphenyl group through cross-coupling reactions. Its reactivity makes it suitable for constructing complex molecular architectures in pharmaceutical and fine chemical research and development.
Organozinc Reagent in Cross-Coupling
3-Methoxyphenylzinc iodide solution is employed in various palladium-catalysed cross-coupling reactions, such as Negishi couplings. It facilitates the formation of carbon-carbon bonds by transferring the 3-methoxyphenyl moiety to organic electrophiles.
Synthesis of Pharmaceutical Intermediates
This reagent serves as a key building block in the synthesis of complex organic molecules, including intermediates for active pharmaceutical ingredients (APIs). Its specific reactivity allows for precise functionalisation in multi-step syntheses.
Aryl Group Introduction
The solution is used to efficiently introduce the 3-methoxyphenyl group into target molecules. This is particularly useful in medicinal chemistry for modifying lead compounds and exploring structure-activity relationships.
| Molecular weight | 299.42 |
|---|---|
| Linear formula | CH3OC6H4ZnI |
| Density | 0.999 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Methoxyphenylzinc iodide solution used for?
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3-Methoxyphenylzinc iodide solution (CAS: 300825-30-3) is primarily used in organic synthesis, particularly in cross-coupling reactions like Negishi coupling, for introducing the 3-methoxyphenyl group into organic molecules.
What is the CAS number and formula for 3-Methoxyphenylzinc iodide solution?
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The CAS number is 300825-30-3 and the linear formula is CH3OC6H4ZnI.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Methoxyphenylzinc iodide solution at a concentration of 0.5 M in THF. We do not represent this product as USP, BP, or EP grade; it is suitable for research and technical applications.
What are the primary safety hazards associated with this product?
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This product is highly flammable (H225) and can form explosive peroxides (Supplemental Hazard Statement, May form explosive peroxides.). It is also an irritant to the eyes, respiratory system (H319, H335), and may cause cancer (H351). Handle with appropriate personal protective equipment in a well-ventilated area.
How is 3-Methoxyphenylzinc iodide solution packaged and shipped?
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This reagent is typically supplied in THF solution and is classified under UN 2924. Shipping and handling follow strict regulations for flammable and corrosive materials. TSS exports globally.
How can I request a sample or quote for 3-Methoxyphenylzinc iodide solution?
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To request a sample or obtain a quote, please contact the Tech Serve Solutions sales team through our website or by phone. Please specify the required quantity and delivery location.
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