3-Methoxy-4-nitrobenzyl alcohol
3-Methoxy-4-nitrobenzyl alcohol (CAS: 80866-88-2), with the molecular formula CH3OC6H3(NO2)CH2OH and a molecular weight of 183.16 g/mol, is a chemical compound utilised in organic synthesis. It serves as a building block in the creation of various complex molecules, including pharmaceuticals and research chemicals. This compound is specifically employed in reactions leading to the formation of azides, aldehydes, and substituted hydantoins.
Synthesis of Aryl Azides
3-Methoxy-4-nitrobenzyl alcohol is a precursor in the synthesis of novel aryl azides. These compounds, such as 3-methoxy-4-nitrobenzyl azide, can be further developed for applications like photoaffinity labeling reagents, potentially targeting biological molecules such as tubulin.
Oxidation to Aldehyde
This alcohol can be oxidised to its corresponding aldehyde, 3-methoxy-4-nitrobenzaldehyde. This transformation is a common synthetic step, allowing for further functionalization and elaboration of the benzyl moiety.
Preparation of Hydantoin Derivatives
The compound is utilised in the synthesis pathway for trifluoromethyl-substituted hydantoins. It plays a role in the preparation of intermediates like 4-[3-(2-methylphenyl)ureido]-3-methoxybenzylchloride, essential for constructing these heterocyclic compounds.
| Molecular weight | 183.16 |
|---|---|
| Linear formula | CH3OC6H3(NO2)CH2OH |
| Assay | 99% |
| Application | 3-Methoxy-4-nitrobenzyl alcohol was used in the synthesis of:• 3-methoxy-4-nitrobenzyl azide1• new aryl azides, (Z)-1-(3′-azido-4′-methoxyphenyl)-2-(3″,4″,5″-trimethoxyphenyl)ethane and (Z)-1-(4′-azido-3′-methoxyphenyl)-2-(3″,4″,5″-trimethoxyphenyl)ethane, potentially useful photoaffinity labeling reagents for tubulin2• 3-methoxy-4-nitrobenzaldehyde via oxidation3• 4-[3-(2-methylphenyl)ureido]-3-methoxybenzylchloride, required for syntheses of trifluoromethyl-substituted hydantoins4 |
| Melting point | 95-97 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Methoxy-4-nitrobenzyl alcohol used for?
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3-Methoxy-4-nitrobenzyl alcohol is primarily used as a building block in organic synthesis for the preparation of various derivatives, including aryl azides, aldehydes, and substituted hydantoins. It is valuable in chemical research and the development of new compounds.
What is the CAS number and formula for 3-Methoxy-4-nitrobenzyl alcohol?
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The CAS number for 3-Methoxy-4-nitrobenzyl alcohol is 80866-88-2, and its linear formula is CH3OC6H3(NO2)CH2OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Methoxy-4-nitrobenzyl alcohol with an assay of 99%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade, as it is intended for research and chemical synthesis purposes.
How should 3-Methoxy-4-nitrobenzyl alcohol be handled safely?
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Based on available safety data, 3-Methoxy-4-nitrobenzyl alcohol is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handling requires appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation.
Is 3-Methoxy-4-nitrobenzyl alcohol a controlled substance?
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The provided data does not indicate that 3-Methoxy-4-nitrobenzyl alcohol is a controlled substance.
How can I request a quote or sample?
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To request a quote or a sample of 3-Methoxy-4-nitrobenzyl alcohol, please contact our sales team through the website or by phone. Our export department is experienced in handling international shipments.
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