3-Mercapto-1-propanol
3-Mercapto-1-propanol (CAS 19721-22-3), with the chemical formula HS(CH2CH2CH2)OH, is a versatile organic compound with a molar mass of 92.16 g/mol. This thiol alcohol is primarily recognised for its utility in creating hydrophilic self-assembled monolayers (SAMs). It also serves as a traceless linker in chemical and enzymatic synthesis, particularly for oligosaccharides, making it valuable in materials science and advanced chemical synthesis.
- IUPAC
- 3-Mercaptopropanol

Hydrophilic Self-Assembled Monolayers (SAMs)
3-Mercapto-1-propanol is employed in the formation of hydrophilic SAMs on various surfaces. These ordered molecular layers are crucial for modifying surface properties in microelectronics and sensor development.
Traceless Linker in Synthesis
This compound functions as an effective traceless linker in complex synthetic pathways. Its application is particularly noted in the chemical and enzymatic synthesis of oligosaccharides, facilitating intricate molecular construction.
Organic Building Block
As a bifunctional molecule containing both thiol and hydroxyl groups, 3-Mercapto-1-propanol serves as a fundamental building block in organic synthesis. It enables the introduction of specific functionalities into larger molecules.
Materials Science
The unique properties of 3-Mercapto-1-propanol make it a valuable component in materials science, particularly for applications requiring controlled surface interactions and molecular assembly.
| Molecular weight | 92.16 |
|---|---|
| Linear formula | HS(CH2CH2CH2)OH |
| Assay | 95% |
| Boiling point | 81-82 °C/10 mmHg(lit.) |
| Density | 1.067 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.495(lit.) |
| Application | This compound is used to produce hydrophilic SAMs. Also used as a Traceless Linker for Chemical and Enzymatic Synthesis of Oligosaccharides1 |

Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P312Call a POISON CENTER if you feel unwell
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 85 °C / 185 °F |
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 24/25 |
| Safety statements (S) | 28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Mercapto-1-propanol used for?
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3-Mercapto-1-propanol is used to produce hydrophilic self-assembled monolayers (SAMs) and serves as a traceless linker for the chemical and enzymatic synthesis of oligosaccharides.
What is the CAS number and chemical formula for 3-Mercapto-1-propanol?
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The CAS number is 19721-22-3, and the chemical formula is HS(CH2CH2CH2)OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Mercapto-1-propanol with an assay of 95%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
How should 3-Mercapto-1-propanol be handled safely?
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3-Mercapto-1-propanol is classified with GHS06 symbol and 'Danger' signal word. It carries hazard statements H301 (Toxic if swallowed) and H311 (Toxic in contact with skin). Appropriate personal protective equipment includes eyeshields, face shields, gloves, and a suitable respirator. Always consult the Safety Data Sheet (SDS) before handling.
Is 3-Mercapto-1-propanol packed, shipped, or exported by TSS?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 3-Mercapto-1-propanol, which is available for purchase and international shipment.
How can I request a sample or quote for 3-Mercapto-1-propanol?
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To request a sample or a quote for 3-Mercapto-1-propanol, please visit the Tech Serve Solutions website or contact our sales department directly through the provided contact information.
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