3-(Isocyanato)propyl-functionalized silica gel

CAS 1173022-52-0Chemical Synthesis

3-(Isocyanato)propyl-functionalized silica gel (CAS 1173022-52-0) is a specialized solid support designed for organic synthesis. This chemically modified silica gel features isocyanate functional groups, making it an effective scavenger for primary and secondary amines and alcohols. Its high surface area and defined particle size contribute to efficient reaction kinetics and purification in solid-supported synthesis applications.

IUPAC: Isocyanate-3 functionalized silica gel

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3-(Isocyanato)propyl-functionalized silica gel — chemical structure, CAS 1173022-52-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisScavengersSilica GelSolid Supported SynthesisSpecialty Synthesis

01 /Applications

Amine Scavenging

This silica gel is highly effective at scavenging primary and secondary amines from reaction mixtures. The isocyanate groups readily react with amines to form stable urea linkages, facilitating purification.

Alcohol Scavenging

It functions as a scavenger for alcohols, reacting to form urethane linkages. This application is useful for removing residual alcohols in synthetic processes where their presence may interfere with subsequent steps or product quality.

Solid-Supported Synthesis

The functionalized silica gel serves as a versatile solid support for various synthetic transformations. Its inert silica base and reactive isocyanate groups enable its use in diverse chemical synthesis strategies.

Purification Agent

As a scavenger, it acts as an effective purification agent by selectively binding and removing unwanted amine and alcohol by-products or excess reagents.

02 /Properties

Storage temperature	2-8°C
Particle size	200-400 mesh
Application	Scavenges primary and secondary amines and alcohols.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1173022-52-0

MDL number

MFCD03095967

PubChem substance

24878248

05 /Additional specifications

Surface Area	500 m2/g

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is 3-(Isocyanato)propyl-functionalized silica gel used for?

3-(Isocyanato)propyl-functionalized silica gel (CAS 1173022-52-0) is used primarily as a scavenger for primary and secondary amines and alcohols, and as a solid support in various chemical synthesis applications.

What is the CAS number and chemical formula for this product?

The CAS number is 1173022-52-0. The chemical formula is not provided in the product data.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product as a functionalized silica gel with a surface area of 500 m²/g and a particle size of 200-400 mesh. The specific assay or purity is not detailed, and TSS does not represent this product as USP, BP, or EP grade.

What are the safety and handling recommendations?

This product carries a Warning signal word with hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Recommended personal protective equipment includes a dust mask type N95, eyeshields, and gloves. Handle in a well-ventilated area.

How is 3-(Isocyanato)propyl-functionalized silica gel typically shipped and exported?

This product is stored at 2-8°C. TSS can expertly pack and export this chemical globally, adhering to all relevant shipping regulations for fine chemicals.

How can I request a sample or a quote?

To request a sample or a quote for 3-(Isocyanato)propyl-functionalized silica gel, please contact our sales department through the website or by phone, providing your details and requirements.