3′-Fluoro-4′-methoxyacetophenone
3′-Fluoro-4′-methoxyacetophenone (CAS: 455-91-4) is a fluorinated aromatic ketone with the linear formula FC₆H₃(OCH₃)COCH₃. This compound serves as a valuable building block in organic synthesis, particularly for introducing fluorinated and methoxy-substituted acetophenone moieties into more complex molecules. Its reactivity profile makes it suitable for diverse chemical transformations within research and development settings.

Organic Synthesis Intermediate
This compound is widely utilised as a key intermediate in the synthesis of various organic molecules. Its structure allows for functional group transformations and carbon-carbon bond formations, facilitating the construction of complex chemical architectures.
Pharmaceutical Research
As a fluorinated building block, 3′-Fluoro-4′-methoxyacetophenone finds application in the discovery and development of novel pharmaceutical agents. Fluorine substitution can significantly alter the pharmacokinetic and pharmacodynamic properties of drug candidates.
Material Science Exploration
The unique electronic and structural properties imparted by the fluoro and methoxy groups make this compound of interest in the exploration of new materials with specific optical or electronic characteristics.
| Molecular weight | 168.16 |
|---|---|
| Linear formula | FC6H3(OCH3)COCH3 |
| Assay | 99% |
| Boiling point | 147-148 °C/20 mmHg(lit.) |
| Melting point | 92-94 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3′-Fluoro-4′-methoxyacetophenone used for?
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3′-Fluoro-4′-methoxyacetophenone is primarily used as an intermediate in organic synthesis, particularly in pharmaceutical research and the development of novel materials.
What is the CAS number and formula for 3′-Fluoro-4′-methoxyacetophenone?
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The CAS number is 455-91-4 and the linear formula is FC₆H₃(OCH₃)COCH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3′-Fluoro-4′-methoxyacetophenone with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should 3′-Fluoro-4′-methoxyacetophenone be handled?
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Handle with appropriate personal protective equipment, including Eyeshields, Gloves, and a dust mask type N95 (US). Avoid breathing dust. This compound can cause skin irritation, eye irritation, and respiratory irritation (H315-H319-H335).
Is 3′-Fluoro-4′-methoxyacetophenone suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and can export 3′-Fluoro-4′-methoxyacetophenone worldwide.
How can I request a quote or sample for 3′-Fluoro-4′-methoxyacetophenone?
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Please contact our sales team through our website to request a quote or sample for 3′-Fluoro-4′-methoxyacetophenone.
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