3-Cyanophenylboronic acid MIDA ester
3-Cyanophenylboronic acid MIDA ester (CAS 1257738-14-9, C12H11BN2O4) is an organoboron compound from the Aryl MIDA Boronates class, with a molecular weight of 258.04 g/mol. This stable, easily handled reagent is primarily utilised in Suzuki-Miyaura cross-coupling reactions for the synthesis of complex organic molecules. Its unique MIDA ester protecting group allows for controlled reactivity and purification, making it a valuable building block in pharmaceutical research and fine chemical manufacturing.
- IUPAC
- 3-(6-Methyl-4,8-dioxo-1,3,6,2-dioxazaborocan-2-yl)benzonitrile
Suzuki Cross-Coupling Reactions
This MIDA boronate ester is an effective coupling partner in palladium-catalyzed Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of biaryl compounds and other complex structures.
Organic Synthesis Intermediate
As a versatile building block, 3-Cyanophenylboronic acid MIDA ester is employed in the construction of diverse organic frameworks. Its protected boronate moiety offers stability and selectivity in multi-step synthetic pathways.
Pharmaceutical Research
The compound serves as a key intermediate in the development of novel pharmaceutical agents. Its application in cross-coupling enables the efficient incorporation of the cyanophenyl group into potential drug candidates.
| Molecular weight | 258.04 |
|---|---|
| Empirical formula | C12H11BN2O4 |
| Assay | 97% |
| Application | Suzuki Cross-Coupling with MIDA Boronates |
| Melting point | 256-260 °C |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Cyanophenylboronic acid MIDA ester used for?
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3-Cyanophenylboronic acid MIDA ester is primarily used as a reagent in Suzuki cross-coupling reactions for the synthesis of complex organic molecules and as an intermediate in pharmaceutical research.
What is the CAS number and formula for 3-Cyanophenylboronic acid MIDA ester?
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The CAS number is 1257738-14-9 and the empirical formula is C12H11BN2O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Cyanophenylboronic acid MIDA ester with an assay of 97%. This product is intended for research and laboratory use. TSS does not represent it as USP, BP, or EP grade.
What are the safety considerations for handling 3-Cyanophenylboronic acid MIDA ester?
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3-Cyanophenylboronic acid MIDA ester is classified as Harmful if swallowed (H302). Appropriate personal protective equipment including a dust mask (type N95 US), eyeshields, and gloves should be worn. Handle in a well-ventilated area. Refer to the Safety Data Sheet (SDS) for comprehensive safety information.
How is 3-Cyanophenylboronic acid MIDA ester typically packed and exported?
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Tech Serve Solutions packages this chemical in appropriate containers for safe handling, storage, and international export, adhering to all relevant shipping regulations.
How can I request a sample or quote for 3-Cyanophenylboronic acid MIDA ester?
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To request a sample or obtain a quote, please contact our sales department via the website or email, specifying the product name and CAS number.
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