3-Chloropropionyl chloride
3-Chloropropionyl chloride (CAS 625-36-5), with the linear formula ClCH₂CH₂COCl and a molecular weight of 126.97 g/mol, is a reactive acid halide. It serves as a valuable building block in organic synthesis. Its utility is demonstrated in the preparation of substituted pyrimidines, functionalised polymer resins, and as an intermediate in the synthesis of potential anticancer agents. TSS supplies this chemical for research and development purposes.
Synthesis of Pyrimidine Derivatives
3-Chloropropionyl chloride has been employed in the microwave-promoted liquid-phase synthesis of 3,5-disubstituted 2-thioxotetrahydropyrimidones, showcasing its role in heterocyclic chemistry.
Polymer Resin Modification
This compound is utilised in the preparation of hydrophilic and macroporous polymer resins that are subsequently modified with isothiocyanate groups, enabling tailored material properties.
Intermediate for Pharmaceutical Synthesis
It serves as a key intermediate in the synthesis of diethylaminopropionamido-hydroxy-anthraquinones, which are explored for their potential anticancer activities.
| Molecular weight | 126.97 |
|---|---|
| Linear formula | ClCH2CH2COCl |
| Boiling point | 143-145 °C(lit.) |
| Density | 1.33 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.457(lit.) |
| Application | 3-Chloropropionyl chloride has been used in:• microwave-promoted liquid-phase synthesis of 3,5-disubstituted 2-thioxotetrahydropyrimidin-4-ones1• preparation of hydrophilic and macroporous polymer resins modified with isothiocyanate groups2• synthesis of diethylaminopropionamido-hydroxy-anthraquinones, which are potential anticancer agents3 |
Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 63 °C / 145.4 °F |
| Transport (UN / ADR) | UN 3390 8(6.1) / PGI |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 14-22-26-34 |
| Safety statements (S) | 23-26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloropropionyl chloride used for?
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3-Chloropropionyl chloride is primarily used as a building block in organic synthesis, including the preparation of substituted pyrimidines, functionalised polymer resins, and intermediates for potential pharmaceutical agents.
What is the CAS number and formula for 3-Chloropropionyl chloride?
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The CAS number is 625-36-5 and the linear formula is ClCH₂CH₂COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Chloropropionyl chloride as a technical or research grade chemical. We do not represent it as USP, BP, or EP grade.
How should 3-Chloropropionyl chloride be handled safely?
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3-Chloropropionyl chloride is a corrosive and toxic substance that reacts violently with water. Handle with extreme caution in a well-ventilated area, using appropriate personal protective equipment including a faceshield, goggles, gloves, and a suitable respirator. Avoid contact with skin, eyes, and clothing. Refer to the Safety Data Sheet for detailed handling procedures.
How is 3-Chloropropionyl chloride packed, shipped, and exported?
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3-Chloropropionyl chloride is carefully packed and prepared for shipment according to international regulations for hazardous materials. Tech Serve Solutions is experienced in global export.
How can I request a quote or sample for 3-Chloropropionyl chloride?
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To request a quote or sample, please contact our sales department through the website or provide your requirements via email.
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