(3-Carboxypropyl)triphenylphosphonium bromide
(3-Carboxypropyl)triphenylphosphonium bromide (CAS: 17857-14-6, Formula: HO2C(CH2)3P(C6H5)3Br, MW: 429.29) is a vital phosphonium salt and Wittig reagent. It is primarily employed as a reactant in organic synthesis for carbon-carbon bond formation, particularly in olefination reactions. Its utility extends to the preparation of complex molecules, including pharmaceutical intermediates and biologically active compounds.
- IUPAC
- (4-Hydroxy-4-oxobutyl)triphenylphosphonium bromide
Synthesis of Piperamide Analogs
Used as a reactant for preparing piperamide analogs that act as histone deacetylase (HDAC) inhibitors, exhibiting antitumor activity.
Preparation of Boron-Containing Benzoxaboroles
Serves as a key intermediate in the synthesis of boron-containing benzoxaboroles, which are investigated for their antimalarial properties.
Synthesis of Antimycobacterial Agents
Employed in the preparation of methyl alkenyl quinolones, a class of compounds showing promise as antimycobacterial agents.
Development of Organotin Compounds
Utilised in the synthesis of organotin compounds, which have applications as antifungal agents.
Oleanolic Acid Derivative Synthesis
A reactant in the synthesis of oleanolic acid derivatives studied for their potential as inhibitors of protein tyrosine phosphatase 1B, relevant to diabetes treatment.
| Molecular weight | 429.29 |
|---|---|
| Linear formula | HO2C(CH2)3P(C6H5)3Br |
| Assay | 98% |
| Application | Reactant for preparation of:• Piperamide analogs as histone deacetylase (HDAC) inhibitors with antitumor activity1• Boron-containing benzoxaboroles as antimalarial agents2• Methyl alkenyl quinolones as antimycobacterial agents3• Solandelactone E via Sharpless epoxidation, Taber cyclopropanation, chemoselective reductions and lithiation-borylation-allylation sequence4• Organotin compounds as antifungal agents5• Oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B for negative regulation of insulin pathway (a promising target for treatment of diabetes and obesity)6• 11-oxa prostaglandin analogs with ocular hypotensive activity7 |
| Melting point | 244-247 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (3-Carboxypropyl)triphenylphosphonium bromide used for?
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(3-Carboxypropyl)triphenylphosphonium bromide is used as a reactant in organic synthesis, particularly for C-C bond formation via Wittig reactions and olefination, and in the preparation of various biologically active compounds and pharmaceutical intermediates.
What are the CAS number and chemical formula?
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The CAS number is 17857-14-6 and the chemical formula is HO2C(CH2)3P(C6H5)3Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (3-Carboxypropyl)triphenylphosphonium bromide with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
What are the safety and handling precautions for this chemical?
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This compound is a Warning substance (GHS07) and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation.
How is this chemical shipped and exported?
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Tech Serve Solutions, a specialist global supplier and exporter since 1998, handles the packing, shipping, and export of (3-Carboxypropyl)triphenylphosphonium bromide, adhering to all relevant regulations.
How can I request a sample or quote?
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To request a sample or a quote for (3-Carboxypropyl)triphenylphosphonium bromide, please contact our sales team through the website or by calling us directly.
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