3-Bromo-5-fluorophenylboronic acid MIDA ester
3-Bromo-5-fluorophenylboronic acid MIDA ester (CAS 1257650-61-5) is a versatile organoboron compound with a molecular weight of 329.91 g/mol. Supplied as a white to off-white solid with an assay of 97%, it belongs to the aryl MIDA boronate class. This reagent is primarily utilised in advanced organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the construction of complex molecular architectures.
Suzuki-Miyaura Cross-Coupling Reactions
This compound serves as an efficient coupling partner in Suzuki-Miyaura reactions, facilitating the formation of carbon-carbon bonds. Its MIDA ester functionality offers enhanced stability and ease of handling compared to traditional boronic acids.
Organic Synthesis Intermediate
It is a valuable building block in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals. The bromo- and fluoro- substituents provide handles for further functionalization.
Medicinal Chemistry Research
Used in research and development for the discovery of new therapeutic agents. The presence of both bromine and fluorine on the phenyl ring allows for tailored electronic and steric properties in target molecules.
| Molecular weight | 329.91 |
|---|---|
| Empirical formula | C11H10BBrFNO4 |
| Assay | 97% |
| Application | Suzuki Cross-Coupling with MIDA Boronates |
| Melting point | 106-110 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Bromo-5-fluorophenylboronic acid MIDA ester used for?
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3-Bromo-5-fluorophenylboronic acid MIDA ester is primarily used as a reagent in Suzuki-Miyaura cross-coupling reactions and as a building block in organic synthesis, particularly in medicinal chemistry research.
What are the CAS number and molecular formula for this compound?
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The CAS number is 1257650-61-5. The empirical formula is C11H10BBrFNO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Bromo-5-fluorophenylboronic acid MIDA ester with a minimum assay of 97%. This is a research-grade chemical and TSS does not represent it as USP, BP, EP, or any pharmacopoeia standard.
How should 3-Bromo-5-fluorophenylboronic acid MIDA ester be handled?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling information.
Is this chemical a controlled substance?
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No, 3-Bromo-5-fluorophenylboronic acid MIDA ester is not listed as a controlled substance.
How is this product packed and exported?
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Products are carefully packed to ensure stability and safety during transit, complying with international shipping regulations. Tech Serve Solutions is an experienced global supplier and exporter.
How can I request a quote or sample?
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Please contact our sales team directly via our website or email to request a quote or a sample of 3-Bromo-5-fluorophenylboronic acid MIDA ester.
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