3′-Azido-3′-deoxythymidine
3′-Azido-3′-deoxythymidine (CAS: 30516-87-1), with the molecular formula C10H13N5O4 and a molecular weight of 267.24 g/mol, is a thymidine analog. This azido derivative plays a crucial role in biochemical research and chemical synthesis, particularly as a nucleoside analog. Its primary utility lies in its function as a building block for modified nucleic acids and in studies involving DNA synthesis and viral replication mechanisms.
- IUPAC
- AZT,Azidothymidine,ZDV,Zidovudine
- Synonyms
- AZTAzidothymidineZDVZidovudine
Nucleic Acid Synthesis Research
3′-Azido-3′-deoxythymidine serves as a key intermediate in the synthesis of modified oligonucleotides and DNA probes. Its azido group allows for further functionalization via click chemistry or other conjugation reactions.
Biochemical Studies
This compound is utilized in biochemical research to investigate enzyme mechanisms, particularly those involved in DNA replication and repair. It acts as a substrate or inhibitor in enzymatic assays.
Chemical Biology Tool
As a nucleoside analog, it is employed in chemical biology to explore cellular processes and molecular interactions within biological systems. Its incorporation can be used to study pathways affected by thymidine metabolism.
Organic Synthesis
3′-Azido-3′-deoxythymidine is a valuable reagent in organic synthesis for preparing complex molecules. The azide functionality is versatile, enabling the formation of triazoles, amines, and other nitrogen-containing heterocycles.
| Molecular weight | 267.24 |
|---|---|
| Empirical formula | C10H13N5O4 |
| Assay | ≥98% (HPLC) |
| Solubility | H2O: soluble50 mg/mL |
| Storage temperature | −20°C |
| Melting point | 113-115 °C(lit.) |
Hazard statements
- H351Suspected of causing cancer
Precautionary statements
- P281Use personal protective equipment as required
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 40 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3′-Azido-3′-deoxythymidine used for?
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3′-Azido-3′-deoxythymidine is used in nucleic acid synthesis research, biochemical studies, chemical biology, and organic synthesis as a nucleoside analog and intermediate.
What are the CAS number and molecular formula for 3′-Azido-3′-deoxythymidine?
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The CAS number is 30516-87-1, and the molecular formula is C10H13N5O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3′-Azido-3′-deoxythymidine with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 3′-Azido-3′-deoxythymidine be handled and stored?
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This compound is classified as a suspected mutagen (H351) and requires careful handling. Store at -20°C. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (type N100 US, P1 or P3 EN143), is essential during handling.
Is 3′-Azido-3′-deoxythymidine a controlled substance?
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The provided data does not indicate that 3′-Azido-3′-deoxythymidine (CAS: 30516-87-1) is a controlled substance. Users should always verify local regulations.
How is 3′-Azido-3′-deoxythymidine packed and shipped by TSS?
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Tech Serve Solutions packs and ships 3′-Azido-3′-deoxythymidine according to industry best practices for chemical reagents, ensuring safe transport for global export.
How can I request a quote or sample of 3′-Azido-3′-deoxythymidine?
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To request a quote or sample, please contact our sales department through the TSS website or via direct inquiry, providing your specific requirements.
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