3-Amino-1,2,4-triazole-5-thiol
3-Amino-1,2,4-triazole-5-thiol (CAS: 16691-43-3) is a heterocyclic organic compound with the molecular formula C2H4N4S and a molecular weight of 116.14 g/mol. It functions as a key building block in chemical synthesis, particularly for preparing triazole derivatives. Its applications extend to studying corrosion inhibition and developing advanced sensor technologies.
- IUPAC
- 3-Amino-5-mercapto-1,2,4-triazole
- Synonyms
- 16691-43-3C2H4N4S3-Amino-5-mercapto-1,2,4-triazole

Corrosion Inhibition Studies
This compound has been utilised in research to investigate the inhibition of iron corrosion in saline environments. It serves as a component in studying the effectiveness of certain inhibitors at low concentrations.
Sensor Development
3-Amino-1,2,4-triazole-5-thiol is employed in the preparation of sophisticated sensing materials. Specifically, it has been used in the development of surface-enhanced Raman scattering (SERS) based pH nano- and microsensors utilising silver nanoparticles.
Heterocyclic Synthesis
As a functionalised triazole, it serves as a valuable precursor and building block in organic synthesis for constructing more complex heterocyclic molecules, relevant in medicinal chemistry and materials science.
| Molecular weight | 116.14 |
|---|---|
| Empirical formula | C2H4N4S |
| Assay | 95% |
| Solubility | water: soluble25 mg/mL, clear, faintly yellow to yellow |
| Application | 3-Amino-1,2,4-triazole-5-thiol was used to study the inhibition of corrosion of iron in 3.5% NaCl solutions by low concentrations of ATT and 1,1′-thiocarbonyldiimidazole1. It was used to prepare surface-enhanced Raman scattering based pH nano- and microsensor using silver nanoparticles2. |
| Melting point | >300 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Amino-1,2,4-triazole-5-thiol used for?
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3-Amino-1,2,4-triazole-5-thiol is used in research for studying corrosion inhibition of iron in saline solutions and in the preparation of sensors, such as surface-enhanced Raman scattering (SERS) based pH nanosensors.
What is the CAS number and formula for 3-Amino-1,2,4-triazole-5-thiol?
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The CAS number is 16691-43-3 and the empirical formula is C2H4N4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Amino-1,2,4-triazole-5-thiol with an assay of 95%. This product is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 3-Amino-1,2,4-triazole-5-thiol be handled safely?
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According to GHS classifications, this compound is a warning substance and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Ensure adequate ventilation and avoid breathing dust.
How is 3-Amino-1,2,4-triazole-5-thiol packed and shipped?
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Products are carefully packed according to international shipping regulations and are exported globally by Tech Serve Solutions.
How can I request a sample or quote for 3-Amino-1,2,4-triazole-5-thiol?
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Please contact our sales team via the website or direct email to request a quotation or sample of 3-Amino-1,2,4-triazole-5-thiol.
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