3-Acetylindole
3-Acetylindole (CAS 703-80-0), a heterocyclic organic compound with the formula C10H9NO and a molecular weight of 159.18 g/mol, serves as a valuable building block in chemical synthesis. This indole derivative is primarily utilised as a reactant in the preparation of various biologically active molecules, including potential pharmaceutical agents with antitumor, antiviral, and antibacterial properties. Its structured functionality makes it a key intermediate for complex organic syntheses.
- IUPAC
- 3-Indolyl methyl ketone,NSC 47180,NSC 58084
- Synonyms
- 3-Indolyl methyl ketone, NSC 47180, NSC 58084
Preparation of Antitumor Agents
3-Acetylindole is employed as a reactant in synthesising indole derivatives with demonstrated antitumor activities, including specific oncrasin-1 derivatives that target RNA polymerase II.
Synthesis of Endothelin-1 Antagonists
This compound serves as a key intermediate in the development of endothelin-1 antagonists, which are researched for various therapeutic applications.
Development of Antiviral Compounds
3-Acetylindole is a precursor for synthesising agents targeting viruses such as hepatitis C (NS3/4A serine protease inhibitors) and bovine viral diarrhea virus (BVDV).
Creation of Antibacterial Agents
Its structure is utilised in the synthesis of novel antibacterial compounds, including those effective against multidrug-resistant Staphylococcus aureus strains.
Research into Antimalarial Agents
3-Acetylindole acts as a building block for the creation of potential antimalarial agents investigated for their efficacy.
| Molecular weight | 159.18 |
|---|---|
| Empirical formula | C10H9NO |
| Assay | ≥98.0% (HPLC) |
| Application | Reactant for preparation of:• Indole derivatives as antitumor agents1• Endothelin-1 antagonists2• Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities• Inhibitors of hepatitis C NS3/4A serine protease3• Antibacterial agens against MDR Staphylococcus aureus strains4• Antimalarial agents5• Anti-bovine viral diarrhea virus (BVDV) agents6• HIV-1 integrase inhibitors7• Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release8 |
| Melting point | 188-192 °C(lit.)189-191 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Acetylindole primarily used for?
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3-Acetylindole is primarily used as a reactant and building block in chemical synthesis for preparing various biologically active molecules, including potential antitumor, antiviral, antibacterial, and antimalarial agents.
What are the CAS number and formula for 3-Acetylindole?
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The CAS number for 3-Acetylindole is 703-80-0, and its empirical formula (Hill notation) is C10H9NO.
What grade and purity does Tech Serve Solutions supply for 3-Acetylindole?
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Tech Serve Solutions supplies 3-Acetylindole with a purity of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should 3-Acetylindole be handled safely?
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Handling 3-Acetylindole requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Consult the safety data sheet for full handling and hazard information. Its WGK is 3.
Is 3-Acetylindole a controlled substance?
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The provided data does not indicate that 3-Acetylindole (CAS 703-80-0) is a controlled substance.
How is 3-Acetylindole packed and shipped?
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Tech Serve Solutions packs and exports fine chemicals like 3-Acetylindole according to international shipping regulations to ensure safe transit. Specific packaging details are available upon request.
How can I request a quote or sample for 3-Acetylindole?
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To request a quote or a sample of 3-Acetylindole, please contact our sales team through the website or by phone, providing your contact details and required quantity.
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