3,5-Difluoroaniline
3,5-Difluoroaniline (CAS: 372-39-4) is a fluorinated aromatic amine with a molecular weight of 129.11 g/mol. This compound serves as a valuable building block in organic synthesis. It is primarily utilised in the preparation of more complex fluorinated organic molecules, including specific aniline derivatives. Tech Serve Solutions supplies this chemical with an assay of ≥98.0% (GC), suitable for research and development purposes.
- Synonyms
- F2C6H3NH23,5-Difluorobenzeneamine

Organic Synthesis Intermediate
3,5-Difluoroaniline is employed as a key intermediate in the synthesis of various organic compounds. Its fluorinated structure makes it useful for introducing fluorine atoms into target molecules, which can modify their chemical and physical properties.
Preparation of Substituted Anilines
This compound has been documented for use in the preparation of related aniline derivatives, such as 3,5-difluorodimethylaniline. This highlights its role in creating specifically substituted aromatic amines for further chemical transformations.
Fluorinated Building Block
As a fluorinated building block, 3,5-Difluoroaniline is integral to the development of novel fluorinated materials and pharmaceuticals. The presence of fluorine can enhance metabolic stability, lipophilicity, and binding affinity in biologically active molecules.
| Molecular weight | 129.11 |
|---|---|
| Linear formula | F2C6H3NH2 |
| Assay | ≥98.0% (GC) |
| Application | 3,5-Difluoroaniline has been used in the preparation of 3,5-difluorodimethylaniline1. |
| Melting point | 37-41 °C(lit.)37-41 °C |

Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 75 °C / 167 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 28-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Difluoroaniline used for?
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3,5-Difluoroaniline is used as an intermediate in organic synthesis, particularly for preparing substituted anilines and other fluorinated organic compounds.
What is the CAS number and molecular formula for 3,5-Difluoroaniline?
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The CAS number is 372-39-4, and its linear formula is F2C6H3NH2.
What grade and purity does Tech Serve Solutions supply for 3,5-Difluoroaniline?
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Tech Serve Solutions supplies 3,5-Difluoroaniline with an assay of ≥98.0% (GC). This is a technical/research grade product and is not represented as USP, BP, or EP grade.
How should 3,5-Difluoroaniline be handled safely?
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3,5-Difluoroaniline is classified as harmful if swallowed, in contact with skin, or if inhaled (H302-H312-H332). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used when handling this chemical. Work should be conducted in a well-ventilated area.
How is 3,5-Difluoroaniline packed, shipped, and exported?
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3,5-Difluoroaniline is carefully packed and exported by Tech Serve Solutions in compliance with international shipping regulations for hazardous chemicals. Specific packaging details can be provided upon request.
How can I request a sample or quote for 3,5-Difluoroaniline?
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To request a sample or obtain a quote for 3,5-Difluoroaniline, please contact our sales team through the website or by phone.
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