3,5-Dichloro-2-hydroxybenzenesulfonyl chloride

CAS 23378-88-3Cl2C6H2(OH)SO2ClChemical Synthesis

3,5-Dichloro-2-hydroxybenzenesulfonyl chloride (CAS 23378-88-3) is a specialised organic compound with the linear formula Cl2C6H2(OH)SO2Cl and a molecular weight of 261.51 g/mol. This sulfonyl halide serves as a key building block in organic synthesis, particularly in the creation of complex molecules. Its reactive nature makes it valuable in the development of novel compounds for research and specialised chemical applications, including its use in the synthesis of specific dibenzenesulfonamido derivatives.

IUPAC: 2,4-Dichlorophenol-6-sulfonyl chloride
Synonyms: Cl2C6H2(OH)SO2Cl2,4-Dichlorophenol-6-sulfonyl chloride

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3,5-Dichloro-2-hydroxybenzenesulfonyl chloride (Cl2C6H2(OH)SO2Cl) — chemical structure, CAS 23378-88-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksChemical SynthesisOrganic Building BlocksSulfonyl HalidesSulfur Compounds

01 /Applications

Synthesis of Dibenzene Derivatives

Used as a precursor in the synthesis of (1R,2R)-(+)-1,2-(3,3′,5,5′-tetrachloro-2,2′-dihydroxydibenzenesulfonamido)-1,2-diphenylethane and related cyclohexane analogues, as documented in chemical literature.

Chromogenic Reagent

Employed as a component of a chromogenic system in a one-step kinetic method for the quantitative determination of 5′-nucleotidase activity.

Organic Synthesis Building Block

A versatile intermediate for organic chemists, enabling the introduction of the 3,5-dichloro-2-hydroxybenzenesulfonyl moiety into various molecular structures for research purposes.

02 /Properties

Molecular weight	261.51
Linear formula	Cl2C6H2(OH)SO2Cl
Assay	99%
Application	3,5-Dichloro-2-hydroxybenzenesulfonyl chloride was used in the synthesis of (1R,2R)-(+)-1,2-(3,3′,5,5′-tetrachloro-2,2′-dihydroxydibenzenesulfonamido)-1,2-diphenylethane1 and (1R,2R)-(+)- 1,2-(3,3′,5,5′-tetrachloro-2,2′-dihydroxydibenzenesulfonamido)cyclohexane1. It was used as chromogenic system in one-step kinetic method for the determination of 5′-nucleotidase2.
Melting point	80-83 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 3261 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

23378-88-3

MDL number

MFCD00007432

PubChem substance

24848764

Beilstein registry

2940993

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 3,5-Dichloro-2-hydroxybenzenesulfonyl chloride used for?

This compound is utilised as a building block in organic synthesis, for example, in the preparation of specific dibenzenesulfonamido derivatives and as a chromogenic system in biochemical assays for enzyme determination.

What is the CAS number and chemical formula?

The CAS number is 23378-88-3, and the linear formula is Cl2C6H2(OH)SO2Cl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical with an assay of 99%. It is suitable for laboratory research and chemical synthesis; we do not represent it as USP, BP, or EP grade.

What are the main safety hazards associated with this chemical?

This compound causes severe skin burns and eye damage (H314). Handling requires appropriate personal protective equipment, including eyeshields, chemical-resistant gloves, and respiratory protection.

How is 3,5-Dichloro-2-hydroxybenzenesulfonyl chloride packed and shipped?

This chemical is classified under UN 3261, Class 8, Packing Group II, indicating it is a corrosive solid. It is packed and exported according to stringent international regulations for hazardous materials.

How can I request a sample or quote for 3,5-Dichloro-2-hydroxybenzenesulfonyl chloride?

To request a sample or a quotation, please contact our sales team via the website or by telephone, providing your specific requirements and delivery details.