3,5-Bis(trifluoromethyl)benzamide
3,5-Bis(trifluoromethyl)benzamide (CAS 22227-26-5) is a specialised organic compound with the linear formula (CF3)2C6H3CONH2 and a molecular weight of 257.13. Characterised by its two trifluoromethyl groups, this compound serves as a valuable building block in organic synthesis. It is primarily utilised in the development of complex molecules within the chemical and pharmaceutical research sectors.
- Synonyms
- (CF3)2C6H3CONH2

Organic Synthesis
This compound functions as a key intermediate and building block in the synthesis of diverse organic molecules. Its unique structural features, including the electron-withdrawing trifluoromethyl groups, enable specific reaction pathways for creating novel chemical entities.
Pharmaceutical Research
Utilised in medicinal chemistry research for the development of potential drug candidates. The presence of trifluoromethyl groups can influence pharmacokinetic properties such as lipophilicity and metabolic stability.
Materials Science
May be employed in the synthesis of specialised polymers or functional materials where its fluorinated structure can impart desirable properties like thermal stability or hydrophobicity.
| Molecular weight | 257.13 |
|---|---|
| Linear formula | (CF3)2C6H3CONH2 |
| Assay | 97% |
| Melting point | 163-167 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Bis(trifluoromethyl)benzamide used for?
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3,5-Bis(trifluoromethyl)benzamide (CAS 22227-26-5) is primarily used as a building block in organic synthesis and in pharmaceutical research for developing novel compounds.
What are the CAS number and formula for 3,5-Bis(trifluoromethyl)benzamide?
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The CAS number is 22227-26-5 and the linear formula is (CF3)2C6H3CONH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,5-Bis(trifluoromethyl)benzamide with an assay of 97%. This is suitable for research and chemical synthesis purposes. TSS does not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling 3,5-Bis(trifluoromethyl)benzamide?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A respirator filter of type N95 (US) or P1 (EN143) is recommended. The compound has a WGK rating of 3 in Germany, indicating a higher hazard level.
How is 3,5-Bis(trifluoromethyl)benzamide exported and shipped?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, ensuring compliant and efficient international shipping procedures.
How can I request a quote or sample for 3,5-Bis(trifluoromethyl)benzamide?
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Please contact our sales department via the website or by telephone to request a quotation or a product sample.
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