3-(4-Hydroxyphenyl)propionic acid N-hydroxysuccinimide ester
3-(4-Hydroxyphenyl)propionic acid N-hydroxysuccinimide ester (CAS 34071-95-9, C13H13NO5) is a chemical reagent with a molecular weight of 263.25. This compound serves as a radioiodination precursor and an acylating agent, particularly useful for modifying proteins and peptides with isotopes like 125I. Its fluorescence properties also lend it to applications in structural analysis and proteomics research.
- IUPAC
- N-[(4-Hydroxyhydrocinnamoyl)oxy]succinimide,N-Succinimidyl 3-(4-hydroxyphenyl)propionate,Bolton-Hunter reagent precursor,Rudinger reagent,SHPP
- Synonyms
- N-[(4-Hydroxyhydrocinnamoyl)oxy]succinimideN-Succinimidyl 3-(4-hydroxyphenyl)propionateBolton-Hunter reagent precursorRudinger reagentSHPP
Protein and Peptide Labeling
After radioiodination, this compound functions as an 125I-containing acylating agent for labeling proteins and peptides. This is crucial for various biochemical and molecular biology studies.
Fluorescence-Based Assays
With specific excitation (λex 320 nm) and emission (λem 409 nm) wavelengths in the presence of peroxidase and hydrogen peroxide, it is suitable for fluorescence applications, including protein structural analysis.
Proteomics Research
Its utility in protein modification and structural analysis makes it a valuable reagent in the field of proteomics for investigating protein function and interactions.
Chemical Biology Studies
As an active ester and coupling reagent, it facilitates the covalent modification of biomolecules, aiding in the study of biological processes at the molecular level.
| Molecular weight | 263.25 |
|---|---|
| Empirical formula | C13H13NO5 |
| Assay | ~90% |
| Storage temperature | −20°C |
| Application | After radioiodination of the reagent, it is used as an 125I-containing acylating agent for proteins and peptides. |
| Suitability | suitable for fluorescence |
| Melting point | 132-133 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 320 nm; λem 409 nm in 0.1 M Tris pH 8.8, 2 mM H2O2, peroxidase |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(4-Hydroxyphenyl)propionic acid N-hydroxysuccinimide ester used for?
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It is used as an 125I-containing acylating agent for proteins and peptides after radioiodination, and is suitable for fluorescence-based applications in protein structural analysis and proteomics.
What are the CAS number and formula for this compound?
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The CAS number is 34071-95-9, and the empirical formula (Hill notation) is C13H13NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ~90%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should this chemical be handled safely?
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This compound is classified as an irritant (H315, H319, H335). When handling, wear a dust mask type N95 (US), eyeshields, and gloves. Ensure good ventilation and avoid breathing dust. In case of eye contact, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do.
How is this product packed, shipped, and exported?
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This product is typically stored at -20°C. TSS is a specialist global supplier and exporter of fine chemicals and laboratory reagents.
How can I request a quote or sample?
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Please contact our customer service team via the website or phone to request a quote or sample for 3-(4-Hydroxyphenyl)propionic acid N-hydroxysuccinimide ester.
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