3,4-Dimethoxytoluene
3,4-Dimethoxytoluene (CAS 494-99-5) is an organic compound with the linear formula CH₃C₆H₃(OCH₃)₂ and a molecular weight of 152.19 g/mol. This aromatic ether, also known as 4-Methylveratrole, serves as a valuable building block in chemical synthesis. It is characterised by its ether functionalities and finds utility in research and development settings, particularly in organic chemistry applications. Tech Serve Solutions provides this compound at a purity of 96%.
- IUPAC
- 4-Methylveratrole
- Synonyms
- 4-Methylveratrole1,2-Dimethoxy-4-methylbenzene

Internal Standard in HPLC
3,4-Dimethoxytoluene has been employed as an internal standard in High-Performance Liquid Chromatography (HPLC) analyses. Its use ensures accuracy and reliability in the quantitative determination of other substances within complex mixtures.
Organic Synthesis Intermediate
As an organic building block, 3,4-Dimethoxytoluene is a versatile intermediate for the synthesis of more complex organic molecules. Its structural features make it suitable for various chemical transformations in research laboratories.
Research and Development
This compound is utilised in diverse R&D projects within the chemical and pharmaceutical sectors. Its properties as an ether and an aromatic compound lend themselves to exploration in novel synthetic pathways.
| Molecular weight | 152.19 |
|---|---|
| Linear formula | CH3C6H3(OCH3)2 |
| Assay | 96% |
| Boiling point | 133-135 °C/50 mmHg(lit.) |
| Density | 1.051 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.528(lit.) |
| Application | 3,4-Dimethoxytoluene was used as an internal standard in HPLC quantifications1. |
| Melting point | 22-23 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 84 °C / 183.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-Dimethoxytoluene primarily used for?
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3,4-Dimethoxytoluene is primarily used as an internal standard in HPLC quantifications and as a versatile building block in organic synthesis and research and development projects.
What is the CAS number and formula for 3,4-Dimethoxytoluene?
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The CAS number for 3,4-Dimethoxytoluene is 494-99-5, and its linear formula is CH₃C₆H₃(OCH₃)₂.
What grade and purity does Tech Serve Solutions supply for 3,4-Dimethoxytoluene?
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Tech Serve Solutions supplies 3,4-Dimethoxytoluene with an assay of 96%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 3,4-Dimethoxytoluene be handled safely?
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3,4-Dimethoxytoluene is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It is recommended to wear a dust mask type N95 (US), eyeshields, and gloves when handling. Ensure adequate ventilation and avoid breathing dust/fume/gas/mist/vapours/spray.
Is 3,4-Dimethoxytoluene a controlled substance?
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The provided data does not indicate that 3,4-Dimethoxytoluene is a controlled substance.
How is 3,4-Dimethoxytoluene packed, shipped, or exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific packing, shipping, and export details for 3,4-Dimethoxytoluene are available upon request.
How can I request a sample or a quote for 3,4-Dimethoxytoluene?
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To request a sample or a quote for 3,4-Dimethoxytoluene, please contact our sales team directly through our website or by phone.
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