3-[3-(Trifluoromethyl)phenoxy]benzaldehyde
3-[3-(Trifluoromethyl)phenoxy]benzaldehyde (CAS 78725-46-9), with the molecular formula CF3C6H4OC6H4CHO and a molar mass of 266.22 g/mol, is a specialised organic building block. This aldehyde, characterised by its trifluoromethylphenoxy substituent, serves as a key intermediate in organic synthesis. It is primarily utilised in the preparation of complex organic molecules, including porphyrins and heterocyclic compounds, finding applications in research and development across various chemical disciplines.
- IUPAC
- 3-(α,α,α-Trifluoro-m-tolyloxy)benzaldehyde
![3-[3-(Trifluoromethyl)phenoxy]benzaldehyde (CF3C6H4OC6H4CHO) — chemical structure, CAS 78725-46-9; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F78725-46-9.png&w=3840&q=75)
Synthesis of Porphyrin Derivatives
This benzaldehyde derivative is a crucial precursor in the synthesis of substituted porphyrins, such as 5,10,15,20-tetra[3-(3-trifluoromethyl)phenoxy]porphyrin. These advanced macrocycles are of interest in materials science and photodynamic therapy research.
Intermediate for Heterocyclic Compounds
It serves as a valuable building block for constructing complex heterocyclic systems. An example includes its use in the synthesis of imidazole derivatives, such as 4-{4-naphthalen-2-yl-5-[3-(3-trifluoromethyl-phenoxy)-phenyl]-imidazol-1-yl}-piperidine.
Organic Synthesis Reagent
As a functionalised aldehyde, it is employed in various organic transformations to introduce the 3-(trifluoromethyl)phenoxy moiety into target molecules. This is useful for modifying properties in drug discovery and materials research.
| Molecular weight | 266.22 |
|---|---|
| Linear formula | CF3C6H4OC6H4CHO |
| Assay | 97% |
| Boiling point | 130 °C/1.4 mmHg(lit.) |
| Density | 1.284 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.538(lit.) |
| Application | 3-[3-(Trifluoromethyl)phenoxy]benzaldehyde was used in the synthesis of:• 5,10,15,20-tetra[3-(3-trifluoromethyl)phenoxy]porphyrin1• 4-{4-naphthalen-2-yl-5-[3-(3-trifluoromethyl-phenoxy)-phenyl]-imidazol-1-yl}-piperidine2 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Flash point | >113 °C / >235.4 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-[3-(Trifluoromethyl)phenoxy]benzaldehyde used for?
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3-[3-(Trifluoromethyl)phenoxy]benzaldehyde is primarily used as a building block in organic synthesis, particularly for the preparation of complex molecules like porphyrins and heterocyclic compounds, and in general chemical synthesis.
What are the CAS number and molecular formula for this compound?
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The CAS number is 78725-46-9 and the molecular formula is CF3C6H4OC6H4CHO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 3-[3-(Trifluoromethyl)phenoxy]benzaldehyde be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. This compound has a high flash point (>113 °C) but should be kept away from heat and ignition sources. Consult the Safety Data Sheet for detailed handling information. It carries a WGK Germany rating of 3.
Is this product controlled or scheduled?
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Based on the provided data, there is no indication that this compound is a controlled or scheduled substance.
How is this chemical typically packed, shipped, or exported?
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Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping and export regulations. Specific packaging details are available upon request.
How can I request a sample or a quote for 3-[3-(Trifluoromethyl)phenoxy]benzaldehyde?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team via our website or by phone, providing the CAS number 78725-46-9.
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