2-Pyridinol 1-oxide
2-Pyridinol 1-oxide (CAS: 13161-30-3), with the molecular formula C5H5NO2 and a molecular weight of 111.10 g/mol, is a pyridine derivative. It is primarily utilised as a peptide coupling agent, serving as an effective substitute for 1-hydroxybenzotriazole (HOBt) in various synthetic organic chemistry applications. This compound is a valuable building block for chemical synthesis, particularly within heterocyclic chemistry. TSS offers this chemical with an assay of ≥98.0% (N).
- IUPAC
- 1-Hydroxy-2-pyridone,2-Hydroxypyridine 1-oxide,HOPO
- Synonyms
- 1-Hydroxy-2-pyridone2-Hydroxypyridine 1-oxideHOPO
Peptide Coupling Agent
2-Pyridinol 1-oxide functions as a peptide coupling agent, offering an alternative to traditional reagents like HOBt. It aids in the efficient formation of peptide bonds during the synthesis of peptides and related compounds.
Chemical Synthesis
As a versatile building block, this compound is employed in a range of chemical synthesis pathways. Its structure makes it suitable for introducing pyridine-N-oxide moieties or participating in further functionalisation.
Heterocyclic Chemistry
Within the domain of heterocyclic building blocks, 2-Pyridinol 1-oxide is a useful intermediate. It is particularly relevant in the synthesis and modification of pyridine-based structures.
| Molecular weight | 111.10 |
|---|---|
| Empirical formula | C5H5NO2 |
| Assay | ≥98.0% (N) |
| Application | HOPO is a peptide coupling agent used as a subsititue for HOBt |
| Melting point | 147-152 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 100 °C / 212 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Pyridinol 1-oxide used for?
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2-Pyridinol 1-oxide is primarily used as a peptide coupling agent, functioning as a substitute for HOBt in chemical synthesis, particularly in the construction of peptide bonds and in heterocyclic chemistry.
What are the CAS number and molecular formula for 2-Pyridinol 1-oxide?
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The CAS number for 2-Pyridinol 1-oxide is 13161-30-3, and its molecular formula is C5H5NO2.
What grade and purity does Tech Serve Solutions supply for 2-Pyridinol 1-oxide?
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Tech Serve Solutions supplies 2-Pyridinol 1-oxide with an assay of ≥98.0% (N). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 2-Pyridinol 1-oxide be handled safely?
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2-Pyridinol 1-oxide is classified with GHS07 (Warning) and carries hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.
Is 2-Pyridinol 1-oxide a controlled substance?
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The provided data does not indicate that 2-Pyridinol 1-oxide is a controlled substance.
How can I request a sample or quote for 2-Pyridinol 1-oxide?
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To request a sample or obtain a quote for 2-Pyridinol 1-oxide, please contact our sales department through the website or by phone, providing your specific requirements.
Is 2-Pyridinol 1-oxide exported by TSS?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Pyridinol 1-oxide.
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