2-Propylzinc bromide solution
2-Propylzinc bromide solution (CAS 77047-87-1), with the linear formula (CH3)2CHZnBr and a molecular weight of 188.38, is supplied as a 0.5 M solution in Tetrahydrofuran (THF). This organozinc halide reagent is highly reactive and is primarily utilised in organic synthesis for carbon-carbon bond formation, particularly in cross-coupling reactions. Its ability to introduce the isopropyl group makes it a valuable tool for constructing complex molecular architectures in research and development settings.
- IUPAC
- Isopropylzinc bromide
- Synonyms
- Isopropylzinc bromide
Organic Synthesis Reagent
2-Propylzinc bromide solution serves as a crucial organometallic reagent in the synthesis of complex organic molecules. It facilitates the introduction of the isopropyl group through carbon-carbon bond formation, enabling the construction of diverse molecular structures.
Cross-Coupling Reactions
This compound is particularly effective in various transition metal-catalysed cross-coupling reactions, such as Negishi couplings. It allows for the precise functionalization of organic substrates, contributing to the development of novel pharmaceuticals and materials.
Intermediate Synthesis
As a versatile building block, 2-Propylzinc bromide solution is employed in the synthesis of various chemical intermediates. Its reactivity profile is well-suited for multi-step synthetic pathways in fine chemical manufacturing.
| Molecular weight | 188.38 |
|---|---|
| Linear formula | (CH3)2CHZnBr |
| Density | 0.963 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P422
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -20 °C / -4 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-14/15-19-36/37/38 |
| Safety statements (S) | 16-26-43 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Propylzinc bromide solution primarily used for?
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2-Propylzinc bromide solution is primarily used as a reagent in organic synthesis for carbon-carbon bond formation, particularly in cross-coupling reactions, to introduce the isopropyl group into organic molecules.
What is the CAS number and formula for 2-Propylzinc bromide solution?
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The CAS number for 2-Propylzinc bromide solution is 77047-87-1 and its linear formula is (CH3)2CHZnBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Propylzinc bromide solution at a concentration of 0.5 M in THF. TSS does not represent this product as USP, BP, EP, or any pharmacopoeia grade; it is supplied for research and chemical synthesis purposes.
How should 2-Propylzinc bromide solution be handled safely?
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2-Propylzinc bromide solution is highly flammable and pyrophoric, reacts violently with water, and is corrosive. It requires handling under an inert atmosphere, with appropriate personal protective equipment including eyeshields, gloves, and respiratory protection. It may form explosive peroxides. Store at 2-8°C.
How is 2-Propylzinc bromide solution packed, shipped, and exported?
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2-Propylzinc bromide solution is packed and shipped according to its hazardous material classification (UN 3399 4.3/PG 2). TSS is experienced in global export of such chemicals, adhering to all international shipping regulations.
How can I request a sample or quote for 2-Propylzinc bromide solution?
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To request a sample or quote for 2-Propylzinc bromide solution, please visit the product page on the Tech Serve Solutions website and use the 'Request a Quote' or 'Contact Us' form, or call our sales department directly.
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