2-Methylbenzylmagnesium chloride solution
2-Methylbenzylmagnesium chloride solution (CAS: 29875-05-6), with the linear formula C8H9MgCl, has a molecular weight of 164.92. This Grignard reagent is supplied as a 0.25 M solution in Tetrahydrofuran (THF). It is a valuable organometallic compound used in organic synthesis for the formation of new carbon-carbon bonds. It is frequently employed in the preparation of complex organic molecules and intermediates in the chemical and pharmaceutical industries.
Carbon-Carbon Bond Formation
As a Grignard reagent, 2-Methylbenzylmagnesium chloride is extensively used to introduce the 2-methylbenzyl group into organic molecules. This is typically achieved through nucleophilic addition to carbonyl compounds, epoxides, and other electrophilic species, enabling the construction of more complex molecular architectures.
Synthesis of Pharmaceutical Intermediates
The reagent serves as a key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and their intermediates. Its ability to form new C-C bonds is crucial for assembling the carbon skeletons of various drug candidates.
Organometallic Chemistry Research
It is utilized in academic and industrial research settings to explore new synthetic methodologies and to create novel organometallic compounds with potential applications in catalysis or materials science.
| Molecular weight | 164.92 |
|---|---|
| Linear formula | H3CC6H4CH2MgCl |
| Boiling point | 65 °C |
| Density | 0.920 g/mL at 25 °C |
| Concentration | 0.25 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methylbenzylmagnesium chloride solution used for?
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2-Methylbenzylmagnesium chloride solution is primarily used in organic synthesis for carbon-carbon bond formation, serving as a versatile Grignard reagent in the preparation of complex organic molecules and pharmaceutical intermediates.
What is the CAS number and formula for 2-Methylbenzylmagnesium chloride solution?
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The CAS number is 29875-05-6, and its linear formula is C8H9MgCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methylbenzylmagnesium chloride solution at a concentration of 0.25 M in THF. TSS does not represent this product as USP, BP, or EP grade.
How should 2-Methylbenzylmagnesium chloride solution be handled safely?
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This solution is highly flammable and corrosive. It reacts violently with water and can cause severe burns. Handle with extreme care in a well-ventilated area, wearing appropriate personal protective equipment (gloves, eye protection, protective clothing). Avoid contact with water, acids, and oxidizing agents. Store refrigerated at 2-8°C and away from ignition sources.
Is 2-Methylbenzylmagnesium chloride solution a controlled substance?
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The provided data does not indicate that 2-Methylbenzylmagnesium chloride solution is a controlled substance.
How is 2-Methylbenzylmagnesium chloride solution packed and exported?
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This product is shipped under UN 2924, Hazard Class 8(3), Packing Group II, reflecting its hazardous nature. TSS ensures compliant packaging and export procedures for this material.
How can I request a quote or sample for 2-Methylbenzylmagnesium chloride solution?
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Please contact our sales team via the website or direct email to request a quote or to arrange for a sample of 2-Methylbenzylmagnesium chloride solution.
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